Volume 1 Characterization, Properties and Applications

Published by De Gruyter 2017

Volume 1 Characterization, Properties and Applications

Edited by: Tracey Rouault
With contributions by: Francesco Bonomi , Toshiko Ichiye , Michael Hendrich , Paul Lindahl , Mrinmoy Chakrabarti , Markus Ribbe , Yilin Hu , Oliver Einsle , Joe Jarrett , Russ Hille , Squire Booker , Yvain Nicolet , Juan Fontecilla , Yisong Guo , Li Jikun , Noodleman Louis , Nick Le Brun , Susana L.A. Andrade , Jason Crack , Erin Dodd , Han Wenge , Nicholas D. Lanz , Doros T. Petasis , Thomas Spatzal and Andrew Thomson

Part of the multi-volume work Iron-Sulfur Clusters in Chemistry and Biology

https://doi.org/10.1515/9783110480436

Overview
Contents

About this book

This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960s to elucidation of the roles of iron sulfur clusters as prosthetic groups of enzymes, such as the citric acid cycle enzyme, aconitase, and numerous other proteins, ranging from nitrogenase to DNA repair proteins. The capacity of iron sulfur clusters to accept and delocalize single electrons is explained by basic chemical principles, which illustrate why iron sulfur proteins are uniquely suitable for electron transport and other activities. Techniques used for detection and stabilization of iron-sulfur clusters, including EPR and Mossbauer spectroscopies, are discussed because they are important for characterizing unrecognized and elusive iron sulfur proteins. Recent insights into how nitrogenase works have arisen from multiple advances, described here, including studies of high-resolution crystal structures.

Methods for characterization of FeS proteins.
Industrial applications of enzymes containing FeS clusters.
Historical context of FeS clusters in biochemistry.

Author information

Tracey Rouault, NIH Bethesda, Maryland, USA

Topics

Frontmatter Publicly Available Download PDF	I
Preface Requires Authentication Unlicensed Licensed Download PDF	V
Tracey A. Rouault biography Requires Authentication Unlicensed Licensed Download PDF	VII
Contents Publicly Available Download PDF	IX
List of contributing authors Requires Authentication Unlicensed Licensed Download PDF	XVII
1. Iron-sulfur proteins: a historical perspective Francesco Bonomi and Tracey A. Rouault Requires Authentication Unlicensed Licensed Download PDF	1
2. Chemistry of iron-sulfur clusters Toshiko Ichiye Requires Authentication Unlicensed Licensed Download PDF	11
3. From the quantum chemistry of iron-sulfur clusters to redox energetics and reaction pathways in metalloenzymes Louis Noodleman Requires Authentication Unlicensed Licensed Download PDF	21
4. Bioinorganic spectroscopy of iron sulfur proteins— an overview Yisong Guo and Jikun Li Requires Authentication Unlicensed Licensed Download PDF	77
5. Quantitative interpretation of EPR spectroscopy with applications for iron-sulfur proteins Doros T. Petasis and Michael P. Hendrich Requires Authentication Unlicensed Licensed Download PDF	135
6. The utility of Mössbauer spectroscopy in eukaryotic cell biology and animal physiology Mrinmoy Chakrabarti and Paul A. Lindahl Requires Authentication Unlicensed Licensed Download PDF	163
7. The interstitial carbide of the nitrogenase M-cluster: insertion pathway and possible function Nathaniel S. Sickerman, Markus Ribbe and Yilin Hu Requires Authentication Unlicensed Licensed Download PDF	191
8. The iron-molybdenum cofactor of nitrogenase Thomas Spatzal, Susana L. A. Andrade and Oliver Einsle Requires Authentication Unlicensed Licensed Download PDF	205
9. Biotin synthase: a role for iron-sulfur clusters in the radical-mediated generation of carbon-sulfur bonds Joseph T. Jarrett Requires Authentication Unlicensed Licensed Download PDF	223
10. Molybdenum-containing iron-sulfur enzymes Russ Hille Requires Authentication Unlicensed Licensed Download PDF	249
11. The role of iron-sulfur clusters in the biosynthesis of the lipoyl cofactor Nicholas D. Lanz and Squire J. Booker Requires Authentication Unlicensed Licensed Download PDF	327
12. Iron-sulfur clusters and molecular oxygen: function, adaptation, degradation, and repair Yvain Nicolet and Juan C. Fontecilla-Camps Requires Authentication Unlicensed Licensed Download PDF	359
13. Reactivity of iron-sulfur clusters with nitric oxide Erin L. Dodd, Jason C. Crack, Andrew J. Thomson and Nick E. Le Brun Requires Authentication Unlicensed Licensed Download PDF	387
Index Requires Authentication Unlicensed Licensed Download PDF	439

(Deutsch)

Language: English
Publisher: De Gruyter
Edition: 2nd Edition
Audience: Researchers in inorganic, bioinorganic and biochemistry, biology, drug discovery, pharmacology and chemical engineering.
Pages
- Front matter: 15
- Main content: 447
Illustrations
- Illustrations: 15
- Coloured Illustrations: 100
- Tables: 10
Keywords: Bioinorganic Chemistry; Biochemistry; Iron-sulfur Clusters

eBook

Published: August 21, 2017
ISBN: 9783110480436

Hardcover

Published: August 21, 2017
ISBN: 9783110478501