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Licensed Unlicensed Requires Authentication Published by De Gruyter 2021

Chapter 8 Biocatalytic applications of autotrophic organisms

Hanna C. Grimm, Elif Erdem and Robert Kourist


The autotrophic metabolism enables the fixation of inorganic carbon using energy sources such as light or reduced molecules from the environment. Whole-cell biotransformations in autotrophic cells use these energy modules for the sustainable regeneration of redox cofactors to drive enzymatic redox reactions. While reactions in wild-type hosts target oxidoreductases from the natural enzyme pool, genetic modification of cells allows the production of desired enzymes from different origins. The strategy circumvents disadvantages of traditional recycling systems such as a low atom efficiency and the requirement of sacrificial cosubstrates and paves the way for sustainable future biocatalysis to produce fine chemicals.

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