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Licensed Unlicensed Requires Authentication Published by De Gruyter 2021

Chapter 9 Photocatalysis to promote cell-free biocatalytic reactions

Georg Höfler, Frank Hollmann, Caroline E. Paul, Marine Rauch, Morten van Schie and Sebastien Willot


Cofactors assist enzymes to catalyze reactions and are indispensable and ubiquitous in nature, playing a central role in metabolic pathways. In biocatalysis, common redox cofactors such as nicotinamide, flavin and heme can be activated by light or synthetized to vary redox potentials, leading to different types of reactions for the formation of interesting chiral products, unattainable through classical chemical methods. This chapter will focus on light-driven cell-free biocatalytic reactions activated via their redox cofactors.

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