Solubility in Pharmaceutical Chemistry

Published by De Gruyter 2020

Solubility in Pharmaceutical Chemistry

Edited by: Christoph Saal and Anita Nair

https://doi.org/10.1515/9783110559835

Overview
Contents

About this book

This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.

Includes crucial physicochemical fundamentals, basic principles and methods to study solubility of drugs. Biomedical, chemical and manufacturing aspects are described in the context of medicinal chemistry as well as pharmaceutical industry.

Author information

Christoph Saal, Merck KGaA, Darmstadt, Germany

Anita Nair, Merck KGaA, Darmstadt, Germany

Topics

Frontmatter Publicly Available Download PDF	I
Contents Publicly Available Download PDF	V
List of contributors Publicly Available Download PDF	VII
1. Solubility – definition and basic physicochemical considerations David Elder Requires Authentication Unlicensed Licensed Download PDF	1
2. Solubility and supersaturation Annette Bauer-Brandl and Martin Brandl Requires Authentication Unlicensed Licensed Download PDF	27
3. In Silico methods to predict solubility James L. McDonagh, John Bo Mitchell, David S Palmer and Rachael E. Skyner Requires Authentication Unlicensed Licensed Download PDF	71
4. How solubility influences bioavailability Bernard Faller, Sandrine Desrayaud, Joerg Berghausen, Marc Laisney and Stephanie Dodd Requires Authentication Unlicensed Licensed Download PDF	113
5. Estimation of intraluminal drug solubility Christos Reppas and Maria Vertzoni Requires Authentication Unlicensed Licensed Download PDF	133
6. Biorelevant media Jennifer Dressman Requires Authentication Unlicensed Licensed Download PDF	149
7. The role of solubility to optimize drug substances – a medicinal chemistry perspective Christoph Saal and Klara Valko Requires Authentication Unlicensed Licensed Download PDF	169
8. The role of solubility in optimizing drug products – a pharmaceutical development perspective René Holm Requires Authentication Unlicensed Licensed Download PDF	209
9. The relevance of solid-state forms for solubility Christoph Saal Requires Authentication Unlicensed Licensed Download PDF	229
10. Solubility and phase behaviour from a drug substance manufacturing perspective Wolfgang Beckmann Requires Authentication Unlicensed Licensed Download PDF	259
11. Biowaivers David Elder Requires Authentication Unlicensed Licensed Download PDF	319
List of Abbreviations Requires Authentication Unlicensed Licensed Download PDF	353
Index Requires Authentication Unlicensed Licensed Download PDF	357

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Chemical Engineers, Biochemists, Chemists, Pharmacists, Medicinal Chemists
Pages
- Front matter: 8
- Main content: 362
Illustrations
- Illustrations: 29
- Coloured Illustrations: 74
- Tables: 34
- Coloured Tables: 1
Keywords: Löslichkeit; Wirkstofffreisetzung; Arzneimittel; Formulierung

eBook

Published: January 20, 2020
ISBN: 9783110559835

Hardcover

Published: January 20, 2020
ISBN: 9783110545135