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Licensed Unlicensed Requires Authentication Published by De Gruyter 2021

8 Identification of radicals responsible for DNA cleavage by photolysis of bis-oxime esters

From the book Advanced Ceramics and Applications

  • Jih Ru Hwu , Shwu-Chen Tsay , Shih Ching Hung , Ming-Hua Hsu , Ji-Yuan Ma , Vojislav V. Mitic , Goran Lazovic and Shang-Shing P. Chou


Newly synthesized 9,10-anthraquinone and acenaphthene-1,2-dione derivatives exhibited high potency for DNA scission under photolytic conditions at concentrations of 37 and 6.5 μM, respectively. Results from electron paramagnetic resonance (EPR) experiments reveal that the benzoyloxy radicals and their degraded aryl radical intermediates (rather than bis-iminyl radicals) were mostly responsible for the DNA cleavage.

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