Nucleic Acids Chemistry

Published by De Gruyter 2021

Nucleic Acids Chemistry

Modifications and Conjugates for Biomedicine and Nanotechnology

Edited by: Ramon Eritja

https://doi.org/10.1515/9783110639537

Overview
Contents

About this book

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

Novel backbones for therapeutic nucleic acids

Lipid-, peptide- and protein-oligonucleotide conjugates.

Modified DNA nanostructures

Aptamers and DNA catalysts.

Author information

Prof. Ramon Eritja, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain.

Topics

Frontmatter Publicly Available Download PDF	I
Contents Publicly Available Download PDF	V
List of Contributing Authors Publicly Available Download PDF	VII
1 Methods for the synthesis of oligonucleotides Anna Aviñó, Carme Fàbrega and Ramon Eritja Requires Authentication Unlicensed Licensed Download PDF	1
2 Synthesis of oligonucleotides carrying DNA lesions for DNA repair studies Carme Fàbrega and Ramon Eritja Requires Authentication Unlicensed Licensed Download PDF	45
3 Synthesis of oligonucleotides carrying modified bases for DNA and protein recognition Carme Fàbrega and Ramon Eritja Requires Authentication Unlicensed Licensed Download PDF	87
4 Nonradioactive labeling of oligonucleotides and postsynthetic modification of oligonucleotides Anna Aviñó, Carme Fàbrega and Ramon Eritja Requires Authentication Unlicensed Licensed Download PDF	143
5 Nucleic acids triple helices Ramon Eritja Requires Authentication Unlicensed Licensed Download PDF	187
6 Nucleic acids quadruplex Raimundo Gargallo, Carlos González, Carme Fàbrega, Anna Aviñó and Ramon Eritja Requires Authentication Unlicensed Licensed Download PDF	231
7 Advances in therapeutic oligonucleotide chemistry Andreia F. Jorge, Santiago Grijalvo, Anna Aviñó, Carme Fàbrega and Ramon Eritja Requires Authentication Unlicensed Licensed Download PDF	273
8 Oligonucleotide conjugates and DNA nanotechnology Andreia F. Jorge, Santiago Grijalvo, Anna Aviñó, Carme Fàbrega and Ramon Eritja Requires Authentication Unlicensed Licensed Download PDF	331
Index Requires Authentication Unlicensed Licensed Download PDF	359

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Researchers and professionals in biochemistry, pharmaceutical chemistry, molecular biology and medicine
Pages
- Front matter: 8
- Main content: 372
Illustrations
- Illustrations: 118
- Coloured Illustrations: 7
- Tables: 20
Keywords: DNA; RNA; Nucleic Acids; Oligonucleotides; Biochemistry

eBook

Published: January 18, 2021
ISBN: 9783110639537

Hardcover

Published: January 18, 2021
ISBN: 9783110635799