This paper assesses the severity of the crisis of 1315-1322 in the Bresse region of France. The economic documentation for this region is exceptionally good during the period in which it was under the control of the Duchy of Savoy. The accounts of many castellanies are continuously preserved from the end of the thirteenth century to the fifteenth century, which makes it possible to analyze the potential impact of the Dantean anomaly on the rural economy of this region in full detail. To date, scholars have never studied the impact of the depression of 1315-1322 in this region. This paper presents a classical analysis of four series of manorial rolls (Jasseron, Treffort, Pont d’Ain, and Pont-de-Vaux) for the period of 1300-1330. Particular attention is given to variations in crop yields and vineyard production, as well as to price fluctuations and the indirect demographic evidence that the rolls provide.