Licensed Unlicensed Requires Authentication Published by De Gruyter 1987

BIOSYNTHESIS OF HUMAN INSULIN IN YEAST VIA SINGLE-CHAIN PRECURSORS

From the book 19. Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986
Jan Markussen, Ulrik Damgaard, Ivan Diers, Niels Pill, Mogens Trier Hansen, Per Larsen, Fanny Norris, Kjeld Norris, Ole Schou, Leo Snel, Lars Thim and Hans Ole Voigt
https://doi.org/10.1515/9783110864243-041
© 2019 Walter de Gruyter GmbH, Berlin/Munich/Boston
From the book
19. Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986
19. Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986

Chapters in this book (159)

Frontmatter
Preface
Committees
The 19th European Peptide Symposium was supported by
Contents
In memoriam Karel Jost
THE JOSEF RUDINGER MEMORIAL LECTURE: AN INTRODUCTORY NOTE
PREDICTION OF POTENCY AND RECEPTOR SELECTIVITY OF REGULATORY PEPTIDES: THE MEMBRANE COMPARTMENT CONCEPT FIRST JOSEF RUDINGER MEMORIAL LECTURE
FROM PEPTONES TO PEPTIDES - A HISTORICAL RETROSPECT
KNOWLEDGE-BASED DESIGN OF NOVEL PEPTIDES
INSULIN-LIKE GROWTH FACTORS: STRUCTURE-ACTIVITY RELATIONSHIPS
SELECTIVE REMOVAL OF THE 2—BROMOETHYL GROUP IN PEPTIDE SYNTHESIS
SELECTIVE PROTECTION OF CYSTEINE WITH FERROCENE DERIVATIVES
ADVANTAGES AND DISADVANTAGES IN THE USE OF FORMIC ACID IN PEPTIDE SYNTHESIS
DIBENZYL DICARBONATE (Z2O) , A NEW CARBOBENZOXYLATING REAGENT
APPLICATION OF FLUORENYLMETHYL ESTERS IN THE SYNTHESIS OF VIRAL PROTEIN FRAGMENTS
ELECTROCHEMICAL CLEAVAGE OF PROTECTING GROUPS
AMMONOLYSIS MEDIATED SIDE REACTIONS OF ß-T-BUTYL-ASPARTYL PEPTIDES
THE PHENOTHIAZINYL-(10)-CARBONYL (PC) - RESIDUE, A NOVEL AMINO-PROTECTING GROUP FOR PEPTIDE SYNTHESIS
TETRACHLOROETHYL MIXED CARBONATES: THEIR USE IN THE SYNTHESIS OF PEPTIDES
TFMSA/TFA CLEAVAGE AND DEPROTECTION IN SPPS
IS THERE HOPE THAT FOUR COMPONENT CONDENSATIONS WILL BECOME USEFUL FOR PEPTIDE AND PROTEIN CHEMISTRY ?
USE OF FMOC AMINO ACID CHLORIDES IN THE SYNTHESIS OF TACHYKININ SEQUENCES AND INVESTIGATION OF THEIR HISTAMINE RELEASING ACTIVITY
IMPROVED PREPARATION OF CRYSTALLINE N-(9-XANTHYL) AMINO ACID N-CARBOXYANHYDRIDES FOR PEPTIDE SYNTHESIS
THE OPTIMIZATION OF REACTION CONDITIONS FOR PEPTIDE SYNTHESIS BY MEANS OF N,N-BIS/2-OXO-3-OXAZOLIDINYL/PHOSPHORODIAMIDIC CHLORIDE
APPLICATION OF MIXED PHOSPHINIC ANHYDRIDES IN FRAGMENT CONDENSATION OF PEPTIDES
A NEW PRINCIPLE FOR FRAGMENT CONDENSATION OF PEPTIDES
SYMMETRICAL ANHYDRIDE REARRANGEMENT LEADS TO THREE DIFFERENT DIPEPTIDE PRODUCTS
ESTERS OF FMOC-AMINO ACIDS WITH 3,4,-DIHYDRO-3-HYDROXY-4-OXO-1,2,3-BENZOTRIAZINE. A NEW CLASS OF SELF-INDICATING, ACTIVATED INTERMEDIATES FOR SOLID PHASE SYNTHESIS
DESIGN OF REAGENTS FOR SOLID PHASE SYNTHESIS
SYNTHESIS OF THE CARBOHYDRATE-FREE VESPULAKININ 1 BY THE CONTINUOUS FLOW SOLID PHASE PROCEDURE AND BY A COMBINATION OF SOLID PHASE AND SOLUTION SYNTHESIS
FACILE SOLID-PHASE PREPARATION OF PEPTIDES CONTAINING THE CH2NH PEPTIDE BOND ISOSTERE AND APPLICATION TO THE SYNTHESIS OF SOMATOSTATIN (SRIF) OCTAPEPTIDE ANALOGUES
SYNTHESIS OF A KARYOPHILIC PEPTIDE COVALENTLY BOUND TO PHOSPHATIDYLETHANOLAMINE
GEL PHASE 13C NMR INVESTIGATION OF 'HYPER-HIGH LOAD' SOLID (GEL) PHASE SYNTHESIS OF AN LH-RH (1-5) ASSEMBLY
LIQUID PHASE PEPTIDE SYNTHESIS EMPLOYING A PHENOLIC MODIFICATION OF THE POLYETHYLENE GLYCOL SUPPORT
A COMPARISON OF DIFFERENT METHODS FOR THE PREPARATION OF BENZHYDRYLAMINE RESINS
THIOETHER LINKAGES BETWEEN PEPTIDE SYNTHETIC INTERMEDIATES AND SOLID SUPPORTS
SOLID PHASE COUPLING OF PROTECTED PEPTIDE SEGMENTS. INFLUENCE OF THE POLYMER SUPPORT
ATTEMPTS AT THE SYNTHESIS OF FOLLICLE STIMULATING HORMONE RELEASING PROTEIN (FRP)
PEPTIDE CYCLIZATIONS ON POLYMERIC SUPPORTS - SITE ISOLATION VERSUS SITE - SITE INTERACTION
SOLID PHASE PEPTIDE SYNTHESIS WITH FMOC-AMINO ACIDS AN ALTERNATIVE PROTOCOL
USE OF PROTEASES FOR THE SYNTHESIS OF LH-RH
BIOSYNTHESIS OF HUMAN INSULIN IN YEAST VIA SINGLE-CHAIN PRECURSORS
STUDIES ON SYSTEM PROPERTIES INFLUENCING THE PARTITION CONSTANT IN KINETICALLY CONTROLLED ENZYMATIC PEPTIDE SYNTHESIS
ENZYMATIC SYNTHESIS OF ASPARTAME. A STUDENT EXPERIMENT
ENZYMATIC SYNTHESIS OP FRAGMENTS OF THE GONADOTROP RELEASING HORMONE MOLECULE WITH LH-RH/FSH-RH ACTIVITY
NUCLEOPHILE BINDING IN CHYMOTRVPSIN PEPTIDE SYNTHESIS
SYNTHESIS AND PROPERTIES OF [Hse65, Ala 81], [Hse65 , Leu81 - and [Hse65 ,Val81] - CYTOCHROME
ENZYMATIC SEMISYNTHESES WITH INSULIN: PREPARATION OF (ARG B31) INSULIN
ENZYME-ASSISTED SEMISYNTHESIS OF POLYPEPTIDE ACTIVE ESTERS FOR SUBSEQUENT SPONTANEOUS COUPLING
CHARACTERIZATION OF SYNTHETIC PEPTIDE HORMONE ANALOGS AND OF BYPRODUCTS
DDZ-, A HIGHLY EFFICIENT PROTECTING GROUP IN LARGE SCALE SYNTHESES OF THYMOSIN-alpha 1 RELATED PEPTIDES
CHEMICAL SYNTHESIS OF TRICHOTOXIN, A MEMBRANE ACTIVE POLYPEPTIDE MYCOTOXIN
CHEMICAL PHOSPHORYLATION OF SERINE PEPTIDES RELATED TO SUBSTRATES OF CYCLIC AMP-DEPENDENT PROTEIN KINASE
COMPARISON OF FOUR APPROACHES TO THE SYNTHESIS OF RAT ATRIAL NATRIURETIC POLYPEPTIDE (ANP)
SEQUENCE ANALYSIS OF THE ANTIBIOTIC EPIDERMIN, A HETERODET TETRACYCLIC 21-PEPTIDE AMIDE
ISOLATION AND STRUCTURE IDENTIFICATION OF A NEW MAST CELL DEGRANULATING PENTADECAPEPTIDE FROM PARAI/E5PULA VULGARIS
PEPTIDES CONTAINING ɑɑ-DISUBSTITUTED AMINO ACIDS. EXPERIMENTS RELATED TO ɑ-HYDROXYMETHYLSERINE
PROTAMINES - VI. TOTAL SYNTHESIS OF [PERORNITHINE]-THYNNINE Z1 AND AMIDINATION STUDIES
MULTIPLE POSITIONS 3H-LABELLING OF GROWTH HORMONE RELEASING FACTORS
THE SYNTHESIS OF CYSTEINE-CONTAINING FRAGMENTS (RESIDUES 6-12 AND 13-20) OF CLOSTRIDIUM BUTXRICUM APOFERREDOXIN
LABELLED [pGlu4 , Cyt6]AVP-(4-8): FAILURE TO LABEL PROLINE WITH TRITIUM BUT SUCCESSFUL INTRODUCTION OF [35S]CYSTEINE
CONTRIBUTION TO LANTHIONINE AND CYCLOLANTHIONINE CHEMISTRY
LARGE-SCALE SYNTHESIS OP GRF(1-29) AND (1-44) AMIDES
PRESS-STUD PROTEIN CONJUGATES
INTERNAL MOBILITY OF A CYCLIC PEPTIDE. A ROTATING FRAME RELAXATION STUDY
SYNTHETIC HELICAL PEPTIDES
CONFORMATION—ACTIVITY RELATIONSHIPS IN THE SERIES OF MURAMYL—PEPTIDES
NMR STUDY OF THYMULIN, A THYMIC NONAPEPTIDE HORMONE. INFLUENCE OF Zn(II) COMPLEXATION ON THE CONFORMATIONAL PROPERTIES
OXYGEN-17 NMR STUDIES OF ENKEPHALINS IN AQUEOUS SOLUTION
CONFORMATIONAL STUDY OF NEUROKININ A: COPARISON WITH SUBSTANCE P AND PHYSALAEMIN
THE CONSTRUCTION OF NEW PROTEINS - DESIGN, SYNTHESIS AND CONFORMATIONAL PROPERTIES OF POLYPEPTIDES WITH ßɑß-TOPOLOGY
CONFORMATIONAL STUDIES ON THREE CYCLIC HEXAPEPTIDES RELATED TO THE SEQUENCE 7-11 OF SOMATOSTATIN
STRUCTURAL VERSATILITY OF PEPTIDES FROM Cɑ , ɑ-DIALKYLATED GLYCINES: Acc5 - AND Acc6-CONTAINING PEPTIDES
SYNTHESIS AND X-RAY ANALYSIS OF OLIGOPEPTIDES CONTAINING ɑ-AMINOISOBUTYRIC ACID (AIB)
RENIN INHIBITORS AND SUBSTRATES: CONFORMATIONAL EFFECT OF PEPTIDE BACKBONE MODIFICATIONS
COMMON STRUCTURAL FEATURES FOR CYTOPROTECTION ACTIVITY OF CYCLIC RETRO ANALOGUES OF SOMATOSTATIN
SOLUTION CONFORMATION OF CONOTOXIN GI
PROTON MAGNETIC RESONANCE STUDIES OF ANGIOTENSIN II CONFORMATION: CHEMICAL SHIFTS FOR THE AROMATIC PROTONS OF SELECTED ANALOGUES IN DMSO—d6 AT 40 0MZ.
CONFORMATIONAL STUDIES OF CARBA-ANALOGS OF OXYTOCIN
CONFORMATIONAL ANALYSIS OF CHOLECYSTOKININ CCK27-33 AND CCK26-33 BY 1H NMR SPECTROSCOPY FLUORESCENCE TRANSFER MEASUREMENTS AND CALCULATIONS.
STUDY OF THE ß-TURN CONFORMATION IN PEPTIDES: AN INTRAMOLECULAR CHARGE-TRANSFER COMPLEXES APPROACH
SPECTROSCOPIC STUDIES OF SYNTHETIC PEPTIDE CHEMOATTRACTANTS
A 2D PROTON CONFORMATIONAL ANALYSIS OF TWO SYNTHETIC AMATOXINS ANALOGS
SURFACTANT-INDUCED ORDERED STRUCTURES OF GASTRIN RELATED PEPTIDES
SYNTHESIS AND CONFORMATIONAL STUDY OF CYCLIC HEXAPEPTIDE ANALOGUES OF SOMATOSTATIN : Cyclo(Phe-D-Trp-Lys-Thr-o,m,p-AMPA)
INVESTIGATION OF CARBAZOLCARBONYL-SUBSTITUTED POLY-ɑ-LYSINE, poly[N6(9H-carbazol-9-ylcarbonyl)-lysine]
BIOPHYSICAL PROPERTIES OF SYNTHETIC PRESEQUENCES SUGGEST CONFORMATIONS IMPORTANT FOR PROTEIN LOCALIZATION
HIGH AFFINITY AND IMPROVED SELECTIVITY FOR 6 OPIOID RECEPTORS EXHIBITED BY NEW LINEAR HEXAPEPTIDES
SYNTHESIS AND BIOLOGY OF CYCLIC ENKEPHALIN PSEUDOPEPTIDES
DESIGN AND SYNTHESIS OF RECEPTOR SELECTIVE PEPTIDE NEUROTRANSMITTERS
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF SIDE-CHAIN TO SIDE-CHAIN CYCLIZED OPIOID PEPTIDE ANALOGS
SYNTHESIS AND BIOLOGICAL ACTIVITY OF ENKEPHALIN RELATED GLYCOPEPTIDES
DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY OF SELECTIVE AGONISTS FOR TACHYKININ RECEPTOR SUBTYPES
DISILOXANE-BRIDGED BIOLOGICALLY ACTIVE ANALOGUES OF THE ENKEPHALINS
CHARACTERIZATION OF A THIRD TACHYKININ RECEPTOR (SP-N) IN THE MAMMALIAN NERVOUS SYSTEM
SYNTHESIS OF PEPTIDES CONTAINING REPEATING SEQUENCES OF ENKEPHALIN
SYNTHESIS AND BIOLOGICAL PROPERTIES OF PERIPLANETIN CC-2 COCKROACH NEUROPEPTIDE PROM CORPORA CARDIACA OP PERIPLANETA AMERICANA. L.
A NOVEL µ—SPECIFIC REACTIVE LIGAND OF THE OPIATE RECEPTOR
STUDIES ON CARBOXYL TERMINALLY EXTENDED DERMORPHINS
SYNTHESIS OP ANALOGS OP ENKEPHALIN DERIVATIVES OP 2-D-ALA,5-DESMET- ENKEPHALIN HYDRAZIDE AT THE FIRST AND FOURTH POSITIONS
SYNTHESIS AND PRELIMINARY BIOLOGICAL RESULTS OF DIMERIC DERMORPHIN- -LIKE PEPTIDES
ENKEPHALIN ANALOGUES CONTAINING POLAR AMINO ACID RESIDUES
CONFORMATIONS OF TACHYKININ PEPTIDES IN MEMBRANE ENVIRONMENTS
CONFORMATION ACTIVITY RELATIONSHIP OF A SERIES OF PEPTIDES RELATED TO DERMORPHIN. A 500 MHz NMR STUDY
SYNTHESIS OF CHOLECYSTOKININ PEPTIDES
CYCLIC HEXAPEPTIDE CCK ANTAGONISTS
SYNTHESIS OF PSEUDO-PEPTIDE AND PEPTIDE ANALOGUES OF THE C-TERMINAL HEPTAPEPTIDE OF CHOLECYSTOKININ AND PRELIMINARY RESULTS ON THEIR IN VITRO ACTIVITY ON RAT PANCREATIC ACINI
SURPRISING FINDINGS WITH SOME DELETION-MODIFIED SELECTIVE V2 ANTAGONISTS OF ARGININE VASOPRESSIN
VASOPRESSIN ANALOGS WITH STRONG AGONISTIC - ANTAGONISTIC PROPERTIES
PHOTOREACTIVE AGONISTS AND ANTAGONISTS OF NEUROHYPOPHYSIAL HORMONES FOR RECEPTOR STUDIES
AC TH-PHOTOAFFINITY LABELS, SYNTHESIS AND APPLICATION OF ANALOGUES WITH AGONISTIC AND PARTIAL AGONISTIC PROPERTIES
THE INFLUENCE OF PEPTIDE-RECEPTOR DISSOCIATION RATE CONSTANTS ON RESPONSES TO AND APPARENT POTENCY OF PEPTIDE HORMONES
SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL GROWTH HORMONE RELEASING FACTOR ANALOGS
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF THREE ARGININE VASOPRESSIN ANALOGS WITH 4-HYDR0XYPR0LINE IN POSITION 7
STUDIES WITH PEPTIDES RELATED TO THE SEQUENCE 4-9 OF ACTH
STRUCTURE-ACTIVITY RELATIONSHIPS OF VASOPRESSIN: SYNTHESES OF NEW VASOPRESSIN ANALOGUES
OXYTOCIN ANALOGS CONTAINING TWO DISULFIDE BONDS
SYNTHESIS OF ALA-SUBSTITUTED ANALOGS OF ACTH/αMSH-(4-10) AND THEIR EFFECTS ON STEROIDOGENESIS AND PIGMENT DISPERSION
SYNTHESIS AND BIOLOGICAL ACTION OF ACTH-MSH FRAGMENTS CONTAINING MELPHALAN
NOVEL GnRH AGONISTS CONTAINING L-β-ASPARTIC ACID DERIVATIVES IN POSITION 6
CHARACTERIZATION OF NOVEL SPECIES SPECIFIC GnRH ANALOGS WHICH CAN BE USED FOR THE INDUCED ARTIFICIAL PROPAGATION OF FISHES
SYNTHETIC PEPTIDE ANTAGONISTS OF GLUCAGON
NEW PHOTO-REACTIVE DERIVATIVES OF INSULIN FOR AFFINITY-LABELLING OF THE INSULIN RECEPTOR
SELECTIVE N- AND C-TERMINAL ELONGATION AT A1 AND B30 OF INSULIN: NEW APPROACHES TO PROINSULIN RELATED CONVERSION INTERMEDIATES
SYNTHESIS OF GLUCAGON-LIKE PEPTIDES: DEVELOPMENT OF SPECIFIC ANTISERA AND ANALYSIS OF PROGLUCAGON PROCESSING
STRUCTURE-ACTIVITY STUDIES OF SOMATOSTATIN AHALOGS, SUBSTITUTED AT POSITIONS 4 AND 5
SYNTHESIS OF SOMATOSTATIN ANALOGUES OF REDUCED SUSCEPTIBILITY TOWARDS INTESTINAL ENZYMES
PEPTIDE CONJUGATES AS DIAGNOSTIC REAGENTS IN CLINICAL IMMUNOLOGY
PREDICTION OF HUMAN RENIN EPITOPES USING A NEW COMPUTER ALGORITHM
DESIGN AND SYNTHESIS OF IMMUNOGENIC COMPLEXES BUILT UP OF A PEPTIDE ANTIGEN, GLYCOPEPTIDE ADJUVANT AND POLYMER CARRIER
THYMULIN ANALOGUES FOR PROBING SPECIFIC BINDING SITES ON LYMPHOBLASTOID CELLS
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF ADAMANTYLAMIDE ANALOGS OF MÜRAMYL-DIPEPTIDE (MDP).
IMMUNOGENICITY OF HEPATITIS B SURFACE ANTIGEN SYNTHETIC PEPTIDE ANALOGUES
SYNTHESIS AND ANTIGENIC PROPERTIES OF PEPTIDES CORRESPONDING TO 200-210 SEQUENCE OF p28sis ONCOPROTEIN. COMPARATIVE STUDY OF NG-PROTECTING GROUPS
SYNTHETIC SEQUENCES OF CHOLERA TOXIN B SUBUNIT ARE IMMUNOGENIC PER OS AND DO NOT INDUCE ORAL TOLERANCE
SYNTHESIS OF LARGE NUMBERS OF COVALENTLY BOUND PEPTIDES IN ORDER TO DETERMINE THE SPECIFICITY OF PEPTIDE ANTISERA AT THE LEVEL OF SINGLE AMINO ACIDS
SYNTHESIS AND IMMUNOLOGICAL ACTIVITY OF PEPTIDES OF THE THYMUS GLAND
STRUCTURE-ACTIVITY RELATIONSHIPS STUDIES OF DIPHTHERIA TOXIN USING SYNTHETIC PEPTIDES THAT ELICIT TOXIN-REACTIVE ANTIBODIES
PREPARATION OF SUBSTRATE INHIBITORS OF THE AMIDATING ENZYME IN PORCINE PITUITARY
RE-APPRAISAL OF THE SERINE PROTEASE CATALYTIC MECHANISM: POSSIBLE INVOLVEMENT OF AN ACYL-HISTIDINE INTERMEDIATE
PREPARATION AND PROPERTIES OF SELECTIVELY ε-NH2 ACYLATED PANCREATIC PHOSPHOLIPASES A2
INTRAMOLECULARLY QUENCHED FLUOROGENIC SUBSTRATES FOR AMINOPEPTIDASE P IN HUMAN SERUM
SENSITIVE CHYMOTRYPSIN DETERMINATION USING FLUOROGENIC SUBSTRATES CONTAINING 2-QUINOLINONE DERIVATIVES
SYNTHESIS OF GLYCOPEPTIDES USING THE ALLYL ESTER AND THE ALLYLOXYCARBONYL GROUP AS PROTECTING FUNCTIONS
EVALUATION OF RECEPTOR SITES FOR PLASMODIUM FALCIPARUM (MALARIA) ON HUMAN ERYTHROCYTES. CHEMICAL SYNTHESIS OF PEPTIDES RELEVANT TO GLYCOPHORIN A.
STRUCTURAL REQUIREMENTS FOR DESENSITIZATION OF SMOOTH MUSCLE TO ANGIOTENSIN II
STRUCTURE ACTIVITY RELATIONSHIP ON NEW PEPTIDE INHIBITORS ON THE ANGIOTENSIN CONVERTING ENZYME
FURTHER SYNTHETIC STUDIES ON POSITION 1 OF ANGIOTENSIN II
CONFIRMATION OF DIMERIC STRUCTURE OF HUMAN BETA-ATRIAL NATRIURETIC POLYPEPTIDE (ß-hANP) BY SYNTHESIS
SMALL PEPTIDES MAY BE TISSUE SPECIFIC MITOSIS INHIBITORS INDUCING TERMINAL DIFFERENTIATION
SYNTHESIS AND BIOLOGICAL PROPERTIES OF ANTIPARALLEL AND PARALLEL DIMERS OF α-HUMAN ATRIAL NATRIURETIC PEPTIDE
STRUCTURE-ACTIVITY RELATIONSHIP OF LEPIDOPTERAN, SELF-DEFENCE PEPTIDE PRODUCED BY SILKWORM
BRADYKININ ANTAGONISTS CONTAINING HYDROXYPROLINE
SYNTHESIS OF CHIRAL TETRAMIC ACID. THE INTERMEDIATE IN THE STEREOCONTROLLED PREPARATION OF STATINE ANALOGUES. KEY COMPONENTS IN ASPARTIC PROTEINASES INHIBITORS
AMINO ACIDS ON THE BASIS OF CYCLIC β-DIKETONES - SYNTHESIS AND PHOTOPHYSICAL CHARACTERISTICS
Participants
Authors' Index
Subject Index