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Licensed Unlicensed Requires Authentication Published by De Gruyter July 5, 2005

The Role of Heterotrimeric G Proteins in Platelet Activation

  • S. Offermanns
From the journal


Activation of platelets plays a central role in hemostasis as well as in various thromboembolic diseases like myocardial infarction or stroke. Most platelet activating stimuli function through receptors which couple to heterotrimeric G proteins of the Gi, Gq and G12 families. Recent studies have elucidated the roles of individual G proteins in the regulation of platelet functions like shape change, aggregation and granule secretion. The signaling pathways mediated by heterotrimeric G proteins operate synergistically to induce a full activation of platelets. This review summarizes recent progress in the understanding of upstream regulation of platelet activation through G protein-coupled receptors.

Published Online: 2005-07-05
Published in Print: 2000-06-21

Copyright © 2000 by Walter de Gruyter GmbH & Co. KG

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