Accessible Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

The Role of Dipeptidyl Peptidase IV (DP IV) Enzymatic Activity in T Cell Activation and Autoimmunity

D. Reinhold, T. Kähne, A. Steinbrecher, S. Wrenger, K. Neubert, S. Ansorge and S. Brocke
From the journal

Abstract

Activated T lymphocytes express high levels of dipeptidyl peptidase IV (DP IV)/CD26. Recent studies support the notion that DP IV may play an important role in the regulation of differentiation and growth of T lymphocytes. This article gives a short overview on DP IV/CD26 expression and effects on immune cells in vitro and in vivo. A major focus of this review are clinical aspects of the function of CD26 on hematopoietic cells and the potential usage of synthetic DP IV inhibitors as therapeutics in inflammatory disorders.

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Published Online: 2005-06-01
Published in Print: 2002-08-27

Copyright © 2002 by Walter de Gruyter GmbH & Co. KG