Accessible Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Identification of a Signal Transduction Pathway That Regulates MMP-9 mRNA Expression in Glomerular Injury

I. von Lüttichau, R. Djafarzadeh, A. Henger, C. D. Cohen, A. Mojaat, M. Jochum, C. Ries, P. J. Nelson and M. Kretzler
From the journal

Abstract

Podocytes contribute to the filtration barrier within the kidney. The integrinlinked kinase (ILK) plays an important role in podocyte adhesion to the glomerular basement membrane, signal transduction and phenotype regulation. We demonstrate that ILK activity is also associated with upregulation of matrix metalloproteinase 9 (MMP-9) mRNA levels during podocyte stress. A synthetic ILK inhibitor blocked MMP-9 mRNA upregulation but showed no effect on TIMP-1 or MMP-2 mRNA expression. Interestingly, a corresponding increase in MMP-9 secretion was not observed, suggesting that MMP-9 mRNA production in podocytes is regulated via ILK, whereas additional signaling pathways may mediate the posttranscriptional regulation of MMP-9.

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Published Online: 2005-06-01
Published in Print: 2002-08-27

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