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Licensed Unlicensed Requires Authentication Published by De Gruyter August 19, 2008

HIV-1 at the immunological and T-lymphocytic virological synapse

Claudia Haller and Oliver T. Fackler
From the journal

Abstract

Cell-cell transmission of human immunodeficiency virus type 1 (HIV-1) is considered the most effective mode of viral spread in T-lymphocyte cultures. Evidence has accumulated that HIV-1 assembles polarized synaptic-like structures, referred to as virological synapses, as specialized sites of viral transfer. Interestingly, it was recently also discovered that HIV-1 impairs the formation of the structurally similar immunological synapse, thereby modulating exogenous T-lymphocyte stimulation to yield an optimal activation state for productive HIV-1 infection. The careful dissection of these opposing effects will contribute to our understanding of retroviral spread and cellular signal transduction machineries.


Corresponding author

Received: 2008-3-13
Accepted: 2008-7-1
Published Online: 2008-08-19
Published in Print: 2008-10-01

©2008 by Walter de Gruyter Berlin New York