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Licensed Unlicensed Requires Authentication Published by De Gruyter August 19, 2008

Sabotage of antiviral signaling and effectors by influenza viruses

Thorsten Wolff, Florian Zielecki, Marion Abt, Daniel Voss, Ilia Semmler and Markus Matthaei
From the journal

Abstract

Vertebrate cells activate multiple signaling modules upon virus infection to eliminate the invading pathogen and to prevent the establishment of a persistent infection. A major immediate response pathway is controlled by the RNA helicases RIG-I and MDA5, which, after recognition of viral nucleic acids, signal induction of the interferon (IFN)-α/β cytokine family that upregulates numerous antiviral effector proteins. Virulent viruses, in contrast, have learned during co-evolution with their hosts to manipulate or avoid this response in order to prevail in a repulsive environment. Focusing on the influenza viruses and their IFN-antagonistic NS1 proteins, we summarize recent progress in this rapidly evolving field at the intersection of virology and immunobiology involving studies of how viral pathogens induce and sabotage cellular defenses.


Corresponding author

Received: 2008-3-26
Accepted: 2008-6-10
Published Online: 2008-08-19
Published in Print: 2008-10-01

©2008 by Walter de Gruyter Berlin New York