Skip to content
Accessible Unlicensed Requires Authentication Published by De Gruyter June 27, 2009

Epidermal growth factor receptor signaling in liver cell proliferation and apoptosis

Roland Reinehr and Dieter Häussinger
From the journal


Recent evidence suggests that epidermal growth factor receptor (EGFR)-dependent signaling contributes to liver cell proliferation, as well as to apoptotic liver cell death, and represents an important regulator of hepatic regeneration. This article summarizes recent findings on the molecular mechanisms involved in EGFR-mediated cell proliferation and apoptosis. The emphasis is on the interplay between EGFR and CD95 (Fas, APO-1) death receptor-signaling, which is determined by the signaling context and liver cell type investigated.

Corresponding author

Received: 2009-3-22
Accepted: 2009-5-11
Published Online: 2009-06-27
Published in Print: 2009-10-01

©2009 by Walter de Gruyter Berlin New York