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Accessible Unlicensed Requires Authentication Published by De Gruyter July 30, 2009

Cellular plasticity of the pancreas

Luc Baeyens and Luc Bouwens
From the journal


Cell replacement therapy holds promises for treatment of patients suffering from diabetes mellitus. When determining the appropriate strategies to amplify the amount of transplantable β-cells, sufficient knowledge of the developmental programs regulating β-cell differentiation is crucial. Here, we describe the plasticity of the different pancreatic cell types in vivo and in vitro and their potential to serve as β-cell progenitor.

Corresponding author

Received: 2009-4-9
Accepted: 2009-6-25
Published Online: 2009-07-30
Published in Print: 2009-10-01

©2009 by Walter de Gruyter Berlin New York