Accessible Requires Authentication Published by De Gruyter August 10, 2007

Antiviral activity of a sulfoquinovosyldiacylglycerol (SQDG) compound isolated from the green alga Caulerpa racemosa

Hui Wang, Yao-Lan Li, Wei-Zai Shen, Wen Rui, Xia-Jun Ma and Ying-Zhou Cen
From the journal

Abstract

An invasive green alga, Caulerpa racemosa, collected from the South China Sea was tested for its antiviral properties. Hot water extracts and the n-butanol fraction obtained showed potent inhibition of herpes simplex virus type 1 (HSV-1) and Coxsackie virus B3 (Cox B3). A sulfoquinovosyldiacylglycerol (SQDG) compound was isolated and purified from the n-butanol fraction following further antiviral-guided fractionation. The SQDG compound exhibited an excellent antiviral effect against HSV-2, with a 50% inhibitory concentration (IC50) of 15.6 μg ml-1 against both standard and clinical strains of HSV-2, but showed only moderate antiviral effects against HSV-1 and Cox B3. The SQDG compound was chemically characterized using spectroscopic methods as (2S)-1,2-di-O-palmitoyl-3-O-(6′-sulfo-α-D-quinovopyranosyl) glycerol. This is the first isolation from C. racemosa of this SQDG compound with notable selective antiviral activity against HSV-2.


Corresponding author

Received: 2006-10-18
Accepted: 2007-6-20
Published Online: 2007-08-10
Published in Print: 2007-08-01

©2007 by Walter de Gruyter Berlin New York