Accessible Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Reduction of Circulating Cholesterol and Apolipoprotein Levels during Sepsis

Peter Fraunberger, Steffen Schaefer, Karl Werdan, Autar K. Walli and Dietrich Seidel
From the journal

Abstract

Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered cholesterol homeostasis. The host response during sepsis is mediated by cytokines and growth factors, which are capable of influencing lipid metabolism. Conversely lipoproteins are also capable of modulating cytokine production during the inflammatory response. Therefore the decrease in circulating cholesterol levels seems to play a crucial role in the pathophysiology of sepsis. In this review the interaction between cytokines and lipid metabolism and its clinical consequences will be discussed.

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Published Online: 2005-06-01
Published in Print: 1999-03-01

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