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Licensed Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Evaluation of the ADVIA® Centaur™ TSH-3 Assay

  • Michael Vogeser , Michael Weigand , Peter Fraunberger , Heike Fischer and Peter Cremer


An analytical evaluation of the thyroid stimulating hormone (TSH-3) assay on the Bayer ADVIA® CentaurTM immunoassay system was performed. General analytical requirements (linearity, resistance to typical interferences, absence of a carry-over effect) were fulfilled and reproducibility was satisfactory. Inter-assay coefficient of variation (CV) of a human serum pool with a concentration of 0.014 mU/l was 22.3%; at concentrations between 0.26 and 83 mU/l CV was below 6%. Method comparison study demonstrated close agreement of TSH results compared to those obtained with the Roche Elecsys® 2010 TSH assay (ADVIA Centaur = 1.08 × Elecsys−0.18 mU/l; r=0.987; n=324). Handling and practicability of the ADVIA Centaur system proved to be convenient with a very high sample throughput. We conclude that the ADVIA Centaur TSH-3 assay meets requirements for clinical use.

Published Online: 2005-06-01
Published in Print: 2000-04-30

Copyright © 2000 by Walter de Gruyter GmbH & Co. KG

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