Accessible Requires Authentication Published by De Gruyter June 1, 2005

Determination of a Redox Compensation Index and Its Relationships to Glycaemic Control in Type 2 Diabetes Mellitus

Lidia Sugherini, Melissa Valentini, Caterina Cambiaggi, Italo Tanganelli, Giorgio Gragnoli, Patrizia Borgogni, Mario Comporti and Alfonso Pompella
From the journal

Abstract

The measurement of single parameters of oxidative stress in biological fluids can often give results difficult to interpret as to the real involvement of oxidative processes in a given disease condition. In the present study we propose a novel integrated parameter, called “redox compensation index”, obtained by combining the results of two established and convenient procedures, i.e. the Fox-2 assay for plasma lipid hydroperoxides and the ferric reducing/antioxidant power (FRAP) assay for total antioxidant potential of plasma. These procedures were employed for the evaluation of oxidative stress in a group of patients with type 2 diabetes mellitus, a condition in which oxidative processes are implicated in the development of complications. In type 2 diabetic patients, plasma lipid hydroperoxides were directly correlated with levels of glycated hemoglobin. On the other hand, a significant inverse correlation was o b s e rved between levels of glycated hemoglobin and redox compensation values. The data reported suggest that the redox compensation index could represent a convenient parameter for the direct appraisal of oxidative status in clinical subjects, and are in support of the proposed role of protein glycation in production of oxidative alterations during type 2 diabetes mellitus.

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Published Online: 2005-06-01
Published in Print: 2000-10-16

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