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Licensed Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Clinical B12 Deficiency in One Case of Recurrent Spontaneous Pregnancy Loss

  • Mirande Candito , Sarah Magnaldo , Jacques Bayle , Jean-François Dor , Yves Gillet , André Bongain and Emmanuel Van Obberghen

Abstract

Moderate hyperhomocysteinaemia (HHcy) and the homozygous mutation C677T in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene are associated with increased risk of recurrent pregnancy loss. This HHcy is currently reported as a consequence of folate rather than of vitamin B12-deficient status. We describe one case of recurrent early pregnancy loss with HHcy caused by B12 deficiency. A 38-year old woman had four episodes of early spontaneous pregnancy loss. Biological data: no haemostasis disorders, HHcy (25.9 μmol/l), normal folate (5 ng/ml), B12 deficiency (<150 pg/ml) and the MTHFR C677T homozygote genotype. A bone marrow biopsy gave evidence of moderate megaloblastosis. Parenteral B12 therapy led to normal homocysteine level within 2 months and to a successful pregnancy. In conclusion, vitamin B12 deficiency is one of the causes of recurrent pregnancy loss associated with HHcy, and serum B12 should be measured systematically in this circumstance.

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Published Online: 2005-06-01
Published in Print: 2003-08-07

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

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