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Licensed Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Carbonyl Stress and Diabetic Complications

  • Toshio Miyata , Naoyoshi Ishikawa and Charles van Ypersele de Strihou
From the journal


Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation end-products (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of “carbonyl stress” in complicated diabetes and, finally, discuss therapeutic perspectives.

Published Online: 2005-06-01
Published in Print: 2003-09-16

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

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