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Licensed Unlicensed Requires Authentication Published by De Gruyter March 7, 2006

Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction

Larry Baum, Ho Keung Ng, Ka Sing Wong, Brian Tomlinson, Timothy Hudson Rainer, Xiangyan Chen, Wing Sze Cheung, Jinling Tang, Wilson Wai San Tam, William Goggins, Cindy See Wai Tong, Daniel Kam Yin Chan, G. Neil Thomas, Ping Chook and Kam Sang Woo

Abstract

Background: Because apolipoprotein E (apoE) and lipopoprotein lipase (LPL) polymorphisms interact with each other and with other factors to affect lipid metabolism, we sought to determine their separate and combined effects in association with ischemic vascular disease.

Methods: We performed a case-control study of 816 subjects: 246 acute ischemic stroke patients, 234 acute myocardial infarction patients, and 336 controls. APOE exon 4 and LPL S447X genotypes were determined.

Results:APOE ɛ2 and ɛ4 homozygotes were increased in stroke (4.5% vs. 1.0%, p=0.008), while in myocardial infarction the ɛ4 allele was increased (12.6% vs. 9.5%, p=0.006) but ɛ2 was decreased (3.7% vs. 12.1%, p=0.000006). For subjects with either APOE ɛ2 or ɛ4 alleles, LPL X alleles were increased in vascular disease (OR=2.2, p=0.01). LPL X alleles displayed opposite tendencies toward association with disease when subjects were divided by sex, smoking, or APOE genotype. Meta-analysis and regression analysis of previous studies supported the sex and smoking dichotomies.

Conclusion: This is the first report of an association of vascular disease with an interaction of APOE exon 4 and LPL S447X genotypes. Therefore, APOE genotypes and LPL S447X interactions with apoE, sex, and smoking may affect the risk of myocardial infarction and ischemic stroke.


Corresponding author: Larry Baum, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong Phone: +852-26323146, Fax: +852-26373852,

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Received: 2005-8-27
Accepted: 2005-12-1
Published Online: 2006-3-7
Published in Print: 2006-3-1

©2006 by Walter de Gruyter Berlin New York