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Licensed Unlicensed Requires Authentication Published by De Gruyter September 11, 2007

Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients

Jaroslav A. Hubacek, Silvie Bloudíčková, Romana Bohuslavová, Petr Táborský, Vladimír Polakovič, Magdaléna Sazamová, Eva Svítilová, Jičí Vlasák, Iva Sojková, Miroslav Ryba, Petr Knetl, Martin Ullrych, Radim Drahozal, Veronika Pavuková, Beata Pavlíková, Drahomíra Fischlová, Magdaléna Mokrejšová, Hana Chmelíčková, Eva Pauchová, Pavel Vyskočil, Zuzana Nýdlová, Jaroslav Kopenec, Petr Fixa, Jan Hajný, Petr Bubeníček, Petr Syrovátka, Jana Zahálková, Stanislav Šurel, Zdeněk Hobzek, Aleš Hrubý, Jana Suchanová, Světlana Vaňková, Jana Brabcová and Ondřej Viklický
From the journal

Abstract

Background: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body's energy balance. We analyzed the association of ghrelin variants with body mass index (BMI), albumin as a marker of malnutrition and plasma lipids as risk factors for atherosclerosis in hemodialyzed patients, in whom malnutrition and accelerated atherosclerosis are common complications.

Methods: Ghrelin variants Arg51>Gln and Leu72> Met were analyzed by PCR-RFLP in 210 hemodialyzed patients, prospectively followed up for 15 months. Changes in body mass index, triglycerides, total cholesterol and albumin over time (after 3, 6, 9, 12 and 15 months of dialysis) were analyzed in subgroups divided according to ghrelin genotypes.

Results: Carriers of at least one of the Gln51 and Met72 alleles lost body weight more quickly than Arg51Arg/Leu72Leu homozygotes (p<0.01). Carriers of the Gln51 allele were at higher risk of developing high cholesterol levels (p<0.01).

Conclusions: Common ghrelin variants may have an effect on changes in biochemical and anthropometric parameters in hemodialyzed patients over time and could be used in the future to plan individualized therapy.

Clin Chem Lab Med 2007;45:1121–3.


Corresponding author: Jaroslav A. Hubacek, IKEM, DEM, – Laboratory for Molecular Genetics, Videnska 1958/9, 140 21, Prague 4, Czech Republic Phone: +420-261-363367, Fax: +420-261-721666,

Received: 2006-9-15
Accepted: 2007-1-11
Published Online: 2007-09-11
Published in Print: 2007-09-01

©2007 by Walter de Gruyter Berlin New York