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Licensed Unlicensed Requires Authentication Published by De Gruyter December 13, 2007

CTLA-4 polymorphism 49A–G is associated with placental abruption and preeclampsia in Finnish women

  • Ester Jääskeläinen , Sari Toivonen , Leea Keski-Nisula , Eeva-Liisa Paattiniemi , Seppo Helisalmi , Kari Punnonen and Seppo Heinonen

Abstract

Background: Our aim was to study genetic variability in the gene encoding cytotoxic T-lymphocyte antigen (CTLA-4) and individual susceptibility to the development of preeclampsia or placental abruption.

Methods: A total of 361 women (132 with preeclampsia, 117 with placental abruption and 112 healthy controls) were genotyped for 49A–G polymorphism (dbSNP: rs231775) in the CTLA-4 gene.

Results: The frequency of the G alleles was significantly higher in women with preeclampsia than in controls (51.1% vs. 42.0%; OR 1.44, 95% CI 1.01–3.48, p<0.043). Women with placental abruption had decreased frequency of AA genotype (22.2% vs. 35.7%) and significantly more AG or GG genotypes compared with controls (OR 1.94, 95% CI 1.09–2.07, p<0.024). No significant differences were detected in the frequencies of genotype GG (29.5%, 21.4% and 19.6%, respectively) between the three groups.

Conclusions: Our data suggest that the 49A–G polymorphism in the CTLA-4 gene is associated with the development of placental abruption and preeclampsia, with women having the G allele being at risk.

Clin Chem Lab Med 2008;46:169–73.


Corresponding author: Seppo Heinonen, MD, Professor, Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland Phone: +358-17-172325, Fax: +358-17-172486

Received: 2007-5-25
Accepted: 2007-9-22
Published Online: 2007-12-13
Published in Print: 2008-02-01

©2008 by Walter de Gruyter Berlin New York

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