Accessible Requires Authentication Published by De Gruyter April 1, 2008

Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese

Bernard M.Y. Cheung, Kwok Leung Ong, Roberta V. Cheung, Louisa Y.F. Wong, Nelson M.S. Wat, Sidney Tam, Gabriel M. Leung, Chun Ho Cheng, Jean Woo, Edward D. Janus, Chu Pak Lau, Tai Hing Lam and Karen S.L. Lam


Background: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population.

Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort.

Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels.

Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.

Clin Chem Lab Med 2008;46:523–7.

Corresponding author: Prof. Bernard M.Y. Cheung, Department of Clinical Pharmacology, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Vincent Drive, Birmingham B15 2TH, UK Phone: +44-121-4146874, Fax: +44-121-4141355,

Received: 2007-10-15
Accepted: 2008-1-2
Published Online: 2008-04-01
Published in Print: 2008-04-01

©2008 by Walter de Gruyter Berlin New York