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Accessible Unlicensed Requires Authentication Published by De Gruyter June 20, 2008

Insulin-like growth factor-I and complications of prematurity: a focus on bronchopulmonary dysplasia

Ettore Capoluongo, Franco Ameglio and Cecilia Zuppi


At least four premature newborn complications have been reported to be associated with low serum insulin-like growth factor-I (IGF-I) levels: bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis and brain damage. Local IGF-I concentrations have only been reported for bronchopulmonary dysplasia and these findings show that lung IGF-I levels are clearly increased (epithelial lining fluid levels), emphasizing the fact that IGF-I is differently regulated in the general circulation or at local level. The present review discusses the meaning of the association between serum IGF-I amounts and development of complications in premature newborns. Finally, some methodological indications are reported regarding the IGF-I assay procedures. It is important to establish what are the possible relationships between blood levels and those of different compartments involved in the diseases.

Clin Chem Lab Med 2008;46:1061–6.

Corresponding author: Ettore Capoluongo, PhD, Laboratory of Molecular Biology, Department of Biochemistry and Clinical Biochemistry, Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy Phone: +39-0630154250, Fax: +39-0630156706,

Received: 2008-3-7
Accepted: 2008-3-27
Published Online: 2008-06-20
Published in Print: 2008-08-01

©2008 by Walter de Gruyter Berlin New York