Accessible Unlicensed Requires Authentication Published by De Gruyter June 27, 2008

Association of CHRNA2 polymorphisms with overweight/obesity and clinical characteristics in a Korean population

Jinju Kim

Abstract

Background: Genes correlated with nicotine may be important in obesity because of the role of nicotine in food intake.

Methods: To determine if single nucleotide polymorphisms (SNPs) in the neuronal nicotinic acetylcholine receptor α2 subunit gene (CHRNA2) are associated with overweight/obesity, 156 non-obese and 200 overweight/obese Koreans were genotyped for four CHRNA2 SNPs using an Affymetrix Array Chip.

Results: Of four SNPs, only one, rs2043063, was associated with overweight/obesity in the study population (co-dominant, p=0.049; dominant, p=0.027). Associations between the significant SNP and obesity-related clinical characteristics were observed, but these were not significant.

Conclusions: The CHRNA2 rs2043063 SNP might be a risk factor for overweight/obesity in Koreans. Therefore, further studies are needed to investigate whether mutations or common polymorphisms of the CHRNA2 gene represent a risk factor for obesity.

Clin Chem Lab Med 2008;46:1085–9.


Corresponding author: Jinju Kim, Department of Oriental Physiology, College of Pharmacy, University of Kyung Hee, Seoul 130-701, Korea Phone: +82-2-9619437, Fax: +82-2-9680560,

Received: 2008-1-23
Accepted: 2008-4-8
Published Online: 2008-06-27
Published in Print: 2008-08-01

©2008 by Walter de Gruyter Berlin New York