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Licensed Unlicensed Requires Authentication Published by De Gruyter December 22, 2008

Vitamin D: current status and perspectives

  • Etienne Cavalier , Pierre Delanaye , Jean-Paul Chapelle and Jean-Claude Souberbielle


The role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25-OH vitamin D into its most active metabolite, 1,25-(OH)2 vitamin D, has led to a very promising future for this “old” molecule. Indeed, observational studies, and more and more interventional studies, are raising the importance of a significant vitamin D supplementation for not-only skeletal benefits. Among them, 25-OH vitamin D has been found to play an important role in prevention of cancers, auto-immune diseases, cardiovascular diseases, diabetes, and infections. Vitamin D deficiency, defined as serum 25-OH vitamin D levels <30 ng/mL, is very common in our population. The cost/benefit ratio and some recently published studies are clearly now in favor of a controlled and efficient vitamin D supplementation in these patients presenting a 25-OH vitamin D level <30 ng/mL. More attention should also be focused on pregnant and lactating women, as well as children and adolescents.

Clin Chem Lab Med 2009;47:120–7.

Corresponding author: Dr. Etienne Cavalier, Department of Clinical Chemistry, University Hospital of Liege, University of Liege, Domaine du Sart-Tilman, 4000 Liège, Belgium Phone: +32-4-3667692, Fax: +32-4-3667691,

Received: 2008-4-1
Accepted: 2008-10-11
Published Online: 2008-12-22
Published in Print: 2009-02-01

©2009 by Walter de Gruyter Berlin New York

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