Accessible Requires Authentication Published by De Gruyter January 23, 2009

Dipeptidyl peptidase (DP) 6 and DP10: novel brain proteins implicated in human health and disease

Kym McNicholas, Tong Chen and Catherine A. Abbott


Dipeptidyl peptidase (DP) 6 and DP10 are non-enzyme members of the dipeptidyl peptidase IV family, which includes fibroblast activation protein, DP8, and DP9. DP6 and DP10 proteins have been shown to be critical components of voltage-gated potassium (Kv) channels important in determining cellular excitability. The aim of this paper was to review the research to date on DP6 and DP10 structure, expression, and functions. To date, the protein region responsible for modulating Kv4 channels has not been conclusively identified and the significance of the splice variants has not been resolved. Resolution of these issues will improve our overall knowledge of DP6 and DP10 and lead to a better understanding of their role in diseases, such as asthma and Alzheimer's disease.

Clin Chem Lab Med 2009;47:262–7.

Corresponding author: Catherine A. Abbott, School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia Phone: +61-8-8201-2078, Fax: +61-8-8201-3015,

Received: 2008-9-17
Accepted: 2008-11-7
Published Online: 2009-01-23
Published in Print: 2009-03-01

©2009 by Walter de Gruyter Berlin New York