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Licensed Unlicensed Requires Authentication Published by De Gruyter October 21, 2009

Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis

  • Andrea Tesija Kuna , Lovro Lamot , Marijana Miler , Miroslav Harjacek , Ana-Maria Simundic and Nada Vrkic

Abstract

Background: The goal of the study was to assess the presence of antibodies to mutated citrullinated vimentin (anti-MCV) and cyclic citrullinated peptides (anti-CCP) in patients with juvenile idiopathic arthritis (JIA) compared with patients with other juvenile onset rheumatic diseases.

Methods: The study included 56 patients who fulfilled the International League of Associations for Rheumatology (ILAR) classification criteria for JIA, and 17 control patients with other juvenile onset rheumatic diseases. Data on six core outcome variables and the Sharp score were collected for patients with JIA. Sera and synovial fluid, if available, were tested for anti-CCP and anti-MCV antibodies using a commercial enzyme-linked immunosorbent assay (ELISA).

Results: Anti-MCV antibodies were positive in 3/56 (5.4%) and anti-CCP in 1/56 (1.8%) of patients with JIA. Two out of three anti-MCV positive patients (one of them also anti-CCP positive) were found to be rheumatoid factor (RF)-positive with polyarticular disease. Within the control group, anti-MCV was positive in 4/17 (23.5%) patients, while anti-CCP positivity was not observed. No correlation between anti-MCV with anti-CCP antibody levels was found for any of the six core outcome variables or for the adapted Sharp score.

Conclusions: Our results show that antibodies targeting citrullinated proteins are not a useful diagnostic marker for JIA, but can indicate severe patterns of disease in JIA.

Clin Chem Lab Med 2009;47:1525–30.


Corresponding author: Andrea Tesija Kuna, PhD, University Department of Chemistry, “Sestre Milosrdnice” University Hospital, Vinogradska 29, 10000 Zagreb, Croatia Phone/Fax: +385 1 3768 280,

Received: 2009-5-25
Accepted: 2009-7-10
Published Online: 2009-10-21
Published in Print: 2009-12-01

©2009 by Walter de Gruyter Berlin New York

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