Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter May 4, 2010

Cord blood and maternal serum neopterin concentrations in patients with pre-eclampsia

  • Tuncer Cayci , E. Ozgur Akgul , Yasemin Gulcan Kurt , Ibrahim Aydin , Hasan Alacam , Esin Ozkan , Halil Yaman , Erdinc Cakir , Ozgur Deren , Pakize Dogan , Cumhur Bilgi and M. Kemal Erbil

Abstract

Background: Pre-eclampsia is a syndrome characterized by hypertension and proteinuria. The aim of this study was to investigate neopterin concentrations in cord blood and maternal serum in patients with pre-eclampsia and a control group.

Methods: Cord blood and maternal serum neopterin were measured in 21 patients with pre-eclampsia and in 27 control subjects. Neopterin concentrations were measured by high performance liquid chromatography.

Results: Cord blood neopterin concentrations were significantly increased in patients with pre-eclampsia compared to controls (54.3±16.8 vs. 43.4±8.5 nmol/L, p=0.011, respectively). Maternal serum neopterin (257.3±36.8 vs. 150.9±33.8 nmol/L, p<0.001) was also higher in patients with pre-eclampsia.

Conclusions: Cord blood and maternal serum neopterin concentrations are higher in patients with pre-eclampsia. Maternal serum neopterin concentrations used may be used as a marker for the early diagnosis of pre-eclampsia.

Clin Chem Lab Med 2010;48:1127–31.


Corresponding author: Halil Yaman, Department of Medical Biochemistry, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey Phone: +90 312 3043319, Fax: +90 312 3043300, ;

Received: 2010-1-7
Accepted: 2010-2-5
Published Online: 2010-05-04
Published in Print: 2010-08-01

©2010 by Walter de Gruyter Berlin New York

Downloaded on 29.3.2024 from https://www.degruyter.com/document/doi/10.1515/CCLM.2010.213/html
Scroll to top button