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Licensed Unlicensed Requires Authentication Published by De Gruyter October 20, 2010

Standardizing plasma protein measurements worldwide: a challenging enterprise

Giampaolo Merlini , Søren Blirup-Jensen , A. Myron Johnson , Joanna Sheldon , Ingrid Zegers and on behalf of the IFCC Committee on Plasma Proteins (C-PP)


The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma Proteins of the IFCC Scientific Division to achieve worldwide comparability in plasma protein results. We focus on the production of reference materials and the methods applied throughout their production process. Particularly, the recent characterization of ERM-DA470k/IFCC and ERM-DA472/IFCC has demonstrated that it is possible to reproduce the earlier established procedures and thereby maintain standardization. Plasma protein reference materials have had a substantial impact in improving the harmonization of patient protein results that should translate into better patient care.

Clin Chem Lab Med 2010;48:1567–75.

Corresponding author: Giampaolo Merlini, Biotechnology Research Laboratories, Fondazione IRCCS Policlinico San Matteo, Department of Biochemistry, University of Pavia, P.le Golgi, 19, 27100 Pavia, Italy Phone: +39-0382-502995, Fax: +39-0382-502990,

Published Online: 2010-10-20
Published in Print: 2010-11-01

©2010 by Walter de Gruyter Berlin New York

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