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Licensed Unlicensed Requires Authentication Published by De Gruyter August 11, 2011

The relationship between serum magnesium levels wıth childhood obesity and insulin resistance: a review of the literature

Nurullah Çelik, Nesibe Andiran and Ayse Esra Yilmaz
From the journal


Background: Magnesium, the second most abundant intra­cellular cation, plays a major role in regulating insulin effect and insulin mediated glucose uptake. It has been shown that serum magnesium levels were negatively correlated with HOMA-IR (homeostasis model of insulin resistance) index.

Aim: To investigate the relationship between serum magnesium levels with obesity and insulin resistance in childhood.

Methods: Two hundred and three children and adolescents (117 obese children and 86 controls) were included. Obese cases were also subgrouped according to the presence or absence of insulin resistance (IR) as “IR (+) obese” and “IR (–) obese”, respectively. Serum glucose, insulin and magnesium levels were measured after a 12-h fasting at 8–8.30 a.m. We assessed insulin sensitivity by using HOMA-IR index as a surrogate marker of insulin resistance.

Results: Serum levels of magnesium were significantly lower in the IR (+) obese group than controls (p=0.014). At the same time, there was a positive correlation between serum magnesium levels and body mass index-standard deviation score (BMI-SDS) (r=–0.28, p=0.03) in the IR (–) obese group.

Conclusions: Low serum magnesium levels may contribute to the development of insulin resistance in obese children.

Corresponding author: Nurullah Çelik, MD, Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Fatih University, Ankara, Turkey Phone: +312-2035075, Fax: +312-2213670

Received: 2011-4-20
Accepted: 2011-6-18
Published Online: 2011-08-11
Published in Print: 2011-10-1

©2011 by Walter de Gruyter Berlin Boston

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