Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice

  • J. E. Mijovic , T. Zakar , D. B. Zaragoza and D. M. Olson
From the journal


Objective: We tested whether lipopolysaccharide (LPS)-induced murine preterm birth was delayed by tyrphostins (inhibitors of tyrosine kinases).

Study design: The tyrphostins, AG126 or AG1288, or the prostaglandin endoperoxide H synthase-2 (PGHS-2) inhibitor, NS-398, were administered 2 h before LPS, with LPS, or 2 h after LPS and their effect on gestational length was measured.

Results: Only tyrphostins and NS-398 administered 2h before LPS successfully delayed preterm birth (p < 0.05).

Conclusions: Both tyrphostins AG126 and AG1288 as well as NS-398 inhibited LPS induced preterm birth to the time of normal birth.

Published Online: 2005-06-01
Published in Print: 2002-07-26

Copyright © 2002 by Walter de Gruyter GmbH & Co. KG

Downloaded on 23.3.2023 from
Scroll Up Arrow