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Licensed Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice

J. E. Mijovic, T. Zakar, D. B. Zaragoza and D. M. Olson
From the journal


Objective: We tested whether lipopolysaccharide (LPS)-induced murine preterm birth was delayed by tyrphostins (inhibitors of tyrosine kinases).

Study design: The tyrphostins, AG126 or AG1288, or the prostaglandin endoperoxide H synthase-2 (PGHS-2) inhibitor, NS-398, were administered 2 h before LPS, with LPS, or 2 h after LPS and their effect on gestational length was measured.

Results: Only tyrphostins and NS-398 administered 2h before LPS successfully delayed preterm birth (p < 0.05).

Conclusions: Both tyrphostins AG126 and AG1288 as well as NS-398 inhibited LPS induced preterm birth to the time of normal birth.

Published Online: 2005-06-01
Published in Print: 2002-07-26

Copyright © 2002 by Walter de Gruyter GmbH & Co. KG