Accessible Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum

Gundula Hebisch, Peruka M. Neumaier-Wagner, Renate Huch and Ursula von Mandach
From the journal

Abstract

Aims: To measure maternal serum interleukins (IL) in pregnancy, delivery and early puerperium, and to identify their potential determinants.

Methods: Prospective longitudinal measures of serum IL-1β, IL-6 and IL-8 in 38 healthy pregnant women at antenatal visits, through labor and delivery, with clinical correlates (infection, vaginal hemorrhage and anemia) recorded by questionnaire.

Results: Pregnancy IL levels remained consistently low. IL-1β increased shortly before delivery, then returned to pregnant levels, except where blood loss exceeded 500 ml. IL-6 and IL-8 rose at labor onset and exceeded pregnancy levels through postpartum day three. Postpartum IL-6 was higher after non-elective cesarean section than after spontaneous delivery (P < 0.0001), and where blood loss exceeded 500 ml. IL-6 and IL-8 were higher with systemic infection during delivery (P < 0.0001) and on postpartum day one (P < 0.05); IL-8 was higher in anemia (delivery: P < 0.005; postpartum day 1: P < 0.05). Differences due to delivery mode and systemic infection remained significant after correction for other conditions.

Conclusions: Labor-dependent inflammation increases all IL levels at delivery. Further studies with larger sample sizes are required to establish reference values differentiating physiology from pathology as an aid to peripartum management.

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Corresponding author: Gundula Hebisch, M.D., Gesundheitszentrum für die Frau Bankstraße, CH-8610 Uster. Tel.:+41-43-444-2000, Fax.:+41-43-444-2001, E-mail:

References

1 Alvarez-de-la-Rosa M, FJ Rebollo, R Codoceo, A Gonzalez Gonzalez: Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery. Eur J Obstet Gynecol Reprod Biol88 (2000) 57Search in Google Scholar

2 Arntzen KJ, E Lien, R Austgulen: Maternal serum levels of interleukin-6 and clinical characteristics of normal delivery at term. Acta Obstet Gynecol Scand76 (1997) 55Search in Google Scholar

3 Bahar AM, HW Ghalib, RA Moosa, ZM Zaki, C Thomas, OA Nabri: Maternal serum interleukin-6, interleukin-8, tumor necrosis factor-alpha and interferon-gamma in preterm labor. Acta Obstet Gynecol Scand82 (2003) 543Search in Google Scholar

4 Cauci S, S Guaschino, D De Aloysio, S Driussi, D De Santo, P Penacchioni, et al.: Interrelationships of interleukin-8 with interleukin-1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. Mol Hum Reprod9 (2003) 53Search in Google Scholar

5 Denison FC, RW Kelly, AA Calder: Differential secretion of chemokines from peripheral blood in pregnant compared with non-pregnant women. J Reprod Immunol34 (1997) 225Search in Google Scholar

6 Denison FC, RW Kelly, AA Calder, SC Riley: Cytokine secretion by human fetal membranes, deciduas and placenta at term. Hum Reprod12 (1998) 3560Search in Google Scholar

7 Dinarello CA: Biologic basis for interleukin-1 in disease. Blood87 (1996) 2095Search in Google Scholar

8 Gravett MG, SS Witkin, GJ Haluska, JL Edwards, MJ Cook, MJ Novy: An experimental model for intraamniotic infection and preterm labor in rhesus monkeys. Am J Obstet Gynecol171 (1994) 1660Search in Google Scholar

9 Halgunset J, H Johnsen, AM Kjollesdal, E Qvigstad, T Espevik, R Austgulen: Cytokine levels in amniotic fluid and inflammatory changes in the placenta from normal deliveries at term. Eur J Obstet Gynecol Reprod Biol56 (1994) 153Search in Google Scholar

10 Hebisch G, AA Grauaug, PM Neumaier-Wagner, T Stallmach, A Huch, R Huch: The relationship between cervical dilatation, interleukin-6 and interleukin-8 during term labor. Acta Obstet Gynecol Scand8 (2001) 840Search in Google Scholar

11 Heresbach D, JB Letourneur, I Bahon, M Pagenault, YM Guillou, F Dyard, et al.: Value of early blood Th-1 cytokine determination in predicting severity of acute pancreatitis. Scand J Gastroenterol33 (1998) 554Search in Google Scholar

12 Kelly RW, R Leask, AA Calder: Choriodecidual production of interleukin-8 and mechanisms of parturition. Lancet339 (1992) 776Search in Google Scholar

13 Laham N, GE Rice, GJ Bishop, C Ransome, SP Brennecke: Interleukin-8 concentrations in amniotic fluid and peripheral venous plasma during human pregnancy and parturition. Acta Endocrinol129 (1993) 220Search in Google Scholar

14 Laham N, SP Brennecke, K Bendtzen, GE Rice: Associated-associated increase in interleukin-1 alpha release in vitro by human gestational tissues. J Endocrinol150 (1996) 515Search in Google Scholar

15 Laham N, SP Brennecke, GE Rice: Interleukin-8 release from human gestational tissue explants: effects of gestation, labor, and chorioamnionitis. Biol Reprod61 (1999) 823Search in Google Scholar

16 Makhseed M, R Raghupathy, F Azizieh, R Farhat, N Hassan, A Bandar: Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions. Hum Reprod15 (2000) 2011Search in Google Scholar

17 Makhseed M, R Raghupathy, S El-Shazly, F Azizieh, JA Al-Harmi, MM Al-Azemi: Pro-inflammatory maternal cytokine profile in preterm delivery. Am J Reprod Immunol49 (2003) 3088Search in Google Scholar

18 Maradny EE, N Kanayama, A Halim, K Maehara, T Terao: Stretching of fetal membranes increases the concentration of interleukin-8 and collagenase activity. Am J Obstet Gynecol174 (1996) 843Search in Google Scholar

19 Murtha AP, PC Greig, CE Jimmerson, WN Herbert: Maternal serum interleukin-6 concentration as a marker for impending preterm delivery. Obstet Gynecol91 (1998) 161Search in Google Scholar

20 Nieman DC: Immune response to heavy exertion. J Appl Physiol82 (1997) 13855Search in Google Scholar

21 Roilides E, T Sein, R Schaufele, SJ Chanock, TJ Walsh: Increased serum concentrations of interleukin-10 in patients with hepatosplenic candidiasis. J Infect Dis178 (1998) 589Search in Google Scholar

22 Romero R, ST Parvizi, E Oyarzun, M Mazor, YK Wu, C Avila: Amniotic fluid interleukin-1 in spontaneous labor at term. J Reprod Med35 (1990) 235Search in Google Scholar

23 Romero R, R Gomez, F Ghezzi, BH Yoon, M Mazor, SS Edwin, et al.: A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol179 (1998) 186Search in Google Scholar

24 Santhanam U, C Avila, R Romero, H Viguet, N Ida, S Sakurai, et al.: Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection. Cytokine3 (1991) 155Search in Google Scholar

25 Sennstrom MB, G Ekman, G Westergren-Thorsson, A Malmstrom, B Bystrom, U Endresen, et al.: Human cervical ripening, an inflammatory process mediated by cytokines. Mol Hum Reprod6 (2000) 375Search in Google Scholar

26 Shimaoka Y, Y Hidaka, H Tada, T Nakamura, N Mitsuda, Y Morimoto, et al.: Changes in cytokine production during and after normal pregnancy. Am J Reprod Immunol44 (2000) 1433Search in Google Scholar

27 Stallmach T, G Hebisch, HI Joller-Jemelka, P Orban, J Schwaller, M Engelmann: Cytokine production and visualized effects in the feto-maternal unit. Quantitative and topographic data on cytokines during intrauterine disease. Lab Invest73 (1995) 384Search in Google Scholar

28 Vassiliadis S, A Ranella, L Papadimitriou, A Makrygiannakis, I Athanassakis: Serum levels of pro- and anti-inflammatory cytokines in non-pregnant women, during pregnancy, labor and abortion. Mediators Inflamm7 (1998) 69Search in Google Scholar

29 Yudin MH, DV Landers, L Meyn, SL Hillier: Clinical and cervical cytokine response to treatment with oral or vaginal metronidazole for bacterial vaginosis during pregnancy: a randomized trial. Obstet Gynecol102 (2003) 527Search in Google Scholar

Published Online: 2005-06-01
Published in Print: 2004-11-04

© Walter de Gruyter