Accessible Requires Authentication Published by De Gruyter June 1, 2005

Mother-to-infant vertical transmission of transfusion transmitted virus in South China

Xiao Xin, Zhou Xiaoguang, Zhu Ninghu, Luo Youtong, Xu Liumei and Zhou Boping
From the journal


A nested PCR was used to detect TTV DNA in serum from 490 mother-infant pairs to determine the rate of vertical transmission of TTV in Guangzhou City, P.R. China. TTV DNA was positive in 87 mothers and 12 of their babies, giving a prevalence of 17.8% in pregnant women and a mother-to-child transmission rate of 13.8%. In eight mother-infant pairs, TTV DNA nucleotide sequences from the mothers and their corresponding infants were identical. The homology of Guangzhou TTV and Japanese TTV ranged from 85.3%–98.2% at nucleotide level. TTV infection is common in pregnant women in South China and vertical transmission can occur. Guangzhou’s and Japanese TTV isolates belong to the same genotype.


Corresponding author: Dr. Xin Xiao Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou 510632/P.R. China. Fax: +86-20-38688000, E-mail:


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Published Online: 2005-06-01
Published in Print: 2004-09-01

© Walter de Gruyter