Accessible Requires Authentication Published by De Gruyter June 1, 2005

Maternal and fetal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3, and their relationship to fetal acidosis at delivery

Sharon M. Cooley, Jennifer C. Donnelly, Michael P. Geary, Charles H. Rodeck and Peter C. Hindmarsh
From the journal

Abstract

Objective: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and in fetal cord blood at delivery.

Methods: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, Illinois, USA), with p < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking and in fetal blood by cord blood analysis at delivery. Cord pH was also recorded.

Results: There was no significant correlation between maternal IGF-1, IGF-2, or IGFBP-3 levels and fetal acidosis. However, a significant correlation does exist between cord IGF-1 levels and fetal acidosis.

Conclusion: Fetal cord IGF-1 has a significant correlation with fetal acidosis at delivery.

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Corresponding author: Dr Sharon Cooley, c/o Rotunda Hospital, Parnell Street, Dublin 1/Ireland. Tel.:+353 1 8730700, Fax:+353 1 8726523, E-mail:

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Published Online: 2005-06-01
Published in Print: 2004-09-01

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