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Licensed Unlicensed Requires Authentication Published by De Gruyter November 4, 2004

Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep

Toshiaki Okawa, Shinya Honda, Minoru Sanpei, Tomohiko Ishida, Keiya Fujimori and Akira Sato
From the journal


Aims: To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF (PGF) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF production in near term fetal sheep.

Methods: Hemodynamic parameters were measured during infusion of big ET-1 into the carotid vein in chronically catheterized fetal sheep on day 125 of gestation. Fetal arterial blood samples were obtained for ET-1, PGF) and nitrate/nitrite (NOx) measurements.

Results: ET-1, NOx and PGF plasma concentrations were all significantly higher in fetal compared with the maternal plasma. Big ET-1 significantly decreased fetal systolic and diastolic blood pressure and significantly increased fetal heart rate. Big ET-1 stimulated plasma PGF), but not NOx, concentration.

Conclusions: Circulatory regulating factors in the fetus were up-regulated. The effects of ET-1 on fetal hemodynamic respnse may be mediated via prostacyclin, but not via the NO pathway.


Corresponding author: Toshiaki Okawa, MD, PhD, Department of Obstetrics & Gynecology, Fukushima Medical University School of Medicine, Hikarigaoka 1, 960-1295 Fukushima/Japan. Tel.: +81-24-547-1290, Fax: +81-24-548-3878, E-mail:


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Published Online: 2004-11-04
Published in Print: 2004-11-04

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