Accessible Requires Authentication Published by De Gruyter June 1, 2005

Early prognostic significance of umbilical cord troponin I in critically ill newborns. Prospective study with a control group

Gülcan Türker, Nazan Sarper, Kadir Babaoğlu, Ayşe S Gökalp, Can Duman and A. Engin Arısoy
From the journal

Abstract

Aim: To determine the value of cord blood cardiac troponin I levels (cTnI) as an early prognostic factor in critically ill newborns, and to compare cord cTnI levels with the prognostic value of the score for neonatal acute physiology (SNAP).

Methods: Cord arterial samples were collected routinely for blood gas analysis, and cord venous samples for cTnI and cardiac-specific creatine kinase assay. The study group (n=109) comprised critically ill newborns who required mechanical ventilation. The control group (n=96) comprised newborns who were either completely healthy (n=48) or were followed in a level I neonatal care unit due to moderate-severity problems.

Results: The critically ill newborns had significantly higher cTnI levels than control babies (median [min-max] 1.4 [0–13] vs. 0 [0–1.8] ng/mL, respectively; P<0.001). In critically ill newborns, non-survivors had significantly higher cTnI levels than survivors (median [min-max] 6.6 [1.3–13.0] vs. 1.3 [0–8.0] ng/mL, respectively; P<0.001). Receiver-operator curve analysis revealed that, compared with SNAP, cTnI was a more sensitive predictor of mortality in critically ill newborns (area under curve=0.96; 95% CI=0.90–1.02).

Conclusion: Significantly elevated cord cTnI may be a valuable predictor of mortality in critically ill newborns.

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Corresponding author: Gülcan Türker, M.D., Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Tıp, Fakültesi Kocaeli Üniversitesi Sopalı, Derince, 41900 Kocaeli/Turkey. Tel.: +90-262-2335981; Fax.: +90-262-2335488;

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Published Online: 2005-06-01
Published in Print: 2005-01-01

©2005 by Walter de Gruyter Berlin New York