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Licensed Unlicensed Requires Authentication Published by De Gruyter September 13, 2005

Special relationships between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates

  • Robert Mittendorf , Robert Covert , Anthony G. Montag , Wafic elMasri , Jonathan Muraskas , Kwang-Sun Lee and Peter G. Pryde
From the journal


Objective: To confirm previous known relationships between Fetal Inflammatory Response Syndrome (FIRS) and neonatal bronchopulmonary dysplasia (BPD) and to present information on previously unknown special relationships between inflammatory variables and BPD.

Study design: At delivery, we obtained biological specimens including umbilical cord venous blood for plasma interleukin-6 levels, as well as placental histology and bacteriology. Among other neonatal outcomes, we collected prospective information on BPD.

Results: Of 141 newborns in the study, 16 had BPD; 79% of these had antecedent FIRS, 27% of those without FIRS had BPD. By multivariable regression, only very low birth weight (adjusted [adj] odds ratio [OR] 32.0, 95% Confidence Interval [CI] 5.0 to positive infinity) and FIRS (adj OR 5.7, 95% CI 1.1 to 42.3) remained significant risk factors. Escherichia coli, perhaps due to its pyogenic nature (strongly elicits inflammatory responses), may have had a special relationship with BPD.

Conclusions: In our data, FIRS and neonatal BPD are highly associated. It is possible that certain pyogenic bacteria in the chorioamnion space may be implicated more often than others.

Condensation: Neonates having Fetal Inflammatory Response Syndrome at delivery may later develop BPD. Pyogenic bacteria, such as Escherichia coli, may be implicated more frequently.

Keywords: BPD; FIRS

Corresponding author: Dr. Robert Mittendorf Department of Obstetrics and Gynecology Loyola University Medical Center 2160 First Avenue, Maywood, IL 60153/USA Tel.: +708-216-2465 Fax: +708-216-5669


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Published Online: 2005-09-13
Published in Print: 2005-10-01

©2005 by Walter de Gruyter Berlin New York

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