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Licensed Unlicensed Requires Authentication Published by De Gruyter May 14, 2013

iOCT with surgical microscopes: a new imaging during microsurgery

Eva Maria Lankenau, Marc Krug, Stefan Oelckers, Norbert Schrage, Tino Just and Gereon Hüttmann

Abstract

The optical coherence tomography (OCT) is a non-invasive imaging technique, which recently has found important clinical micrometer applications. It allows noncontact and non-invasive cross-section imaging of the tissues with a depth resolution of about 10 µm. Similar to high-frequency ultrasound, the OCT shows real-time cross-sectional images of the tissue structures and tissue layers in a depth of a few millimeters. The OCT has evolved to an indispensable tool in ophthalmic diagnosis. An emerging application is the intraoperative use of OCT (iOCT). We developed the first commercially available device for the OCT, a universal OCT-Camera, which can be attached to the camera port of the different surgical microscopes. The OCT-Camera is completely integrated into the surgical procedure by enabling the OCT imaging before, during, and after microsurgery without interruption. The individual steps and the outcome of the surgical procedures, such as transplantation of the thin membranes or micro implants, are visualized in real time. The easy handling and first clinical applications of the iOCT were successfully demonstrated.


Corresponding author: Eva Maria Lankenau, OptoMedical Technologies GmbH, Lübeck, Germany

The base technology of the OCT-Camera was developed at the Institute of Biomedical Optics (BMO) at the University of Luebeck in cooperation with Moeller-Wedel GmbH. The OptoMedical Technologies GmbH was formed in 2010 as a spin-off company of the BMO. Supported of the Federal Government (BMWi), Exist Forschungstransfer, Hochschule-Wirtschaft-Transfer, is gratefully acknowledged.

References

[1] D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, et al., Science 254, 1178–1181 (1991).10.1126/science.1957169Search in Google Scholar PubMed PubMed Central

[2] G. Häusler and M.W. Lindner, J. Biomed. Opt. 3, 21 (1998).Search in Google Scholar

[3] G. Hüttmann, R.P. Jackson, S. Guo, J.M. Ridgway, U. Mahmood, et al., Klinisches Monatsblatt Augenheilkunde 226(12), 958 (2009).10.1055/s-0028-1109939Search in Google Scholar PubMed

[4] B.J. Wong, R.P. Jackson, S. Guo, J.M. Ridgway, U. Mahmood, et al., Laryngoscope 115(11), 1904–1911 (2005).10.1097/01.MLG.0000181465.17744.BESearch in Google Scholar PubMed

[5] A. Sepehr, W.B. Armstrong, S. Guo, J. Su, J. Perez, et al., Otolaryngol. Head Neck 138(4), 425 (2008).10.1016/j.otohns.2007.12.005Search in Google Scholar PubMed PubMed Central

[6] T. Just, E. Lankenau, G. Hüttmann, and H.W. Pau, J. Laryngol. Otol. 123, 1027 (2009).Search in Google Scholar

[7] H.W. Pau, E. Lankenau, T. Just, and G. Hüttmann, Acta Otolaryngol. 127(9), 907 (2007).10.1080/00016480601089408Search in Google Scholar PubMed

[8] H.W. Pau, E. Lankenau, T. Just, D. Behrend, and G. Hüttmann. Acta Otolaryngol. 127(9), 920 (2007).10.1080/00016480601075423Search in Google Scholar PubMed

[9] T. Just, E. Lankenau, G. Hüttmann, and H.W. Pau, J. Laryngol. Otol. 123(6), 603 (2009).10.1017/S0022215109004381Search in Google Scholar PubMed

[10] T. Just, E. Lankenau, G. Hüttmann, and H.W. Pau, in ‘Optical Coherence Tomography as a Guide for Cochlear Implant Surgery?’, Ed. By K. Nikiforos et al. Proc. SPIE 6842, San Jose, 1F (2008).10.1117/12.771446Search in Google Scholar

[11] T. Just, E. Lankenau, F. Prall, G. Hüttmann, H.W. Pau, et al., Laryngoscope 120(10), 1964–1970 (2010).10.1002/lary.21057Search in Google Scholar PubMed

[12] T. Just, T. Zehlickea, O. Specht, W. Sass, C. Punke, et al., J. Laryngol. Otol., 125, 467–473 (2011).Search in Google Scholar

[13] H.J. Böhringer, E. Lankenau, F. Stellmacher, E. Reusche, G. Hüttmann, et al., Acta Neurochir. 151, 507–517 (2009).Search in Google Scholar

[14] H.J. Böhringer, D. Boller, J. Leppert, U. Knopp, E. Lankenau, et al., Lasers Surg. Med. 38, 588–597 (2006).Search in Google Scholar

[15] A. Giese, H. J. Böhringer, J. Leppert, S. R. Kantelhardt, E. Lankenau, et al., in ‘Non-Invasive Intraoperative Optical Coherence Tomography of the Resection Cavity During Surgery of Intrinsic Brain Tumors’, Ed. By N. Kollias et al. Photonic Therapeutics and Diagnostics II. Proc. SPIE 6078, 495 (2006).10.1117/12.674436Search in Google Scholar

[16] J. Welzel, E. Lankenau, G. Hüttmann, and R. Birngruber, in ‘Handbook of Optical Coherence Tomography’, Ed. By W. Drexler and J. G. Fujimoto (Springer Berlin, Heidelberg, 2008) pp. 1103ff.10.1007/978-3-540-77550-8_35Search in Google Scholar

[17] E. Lankenau, J. Welzel, R. Birngruber, and R. Engelhardt, in ‘Coherence Domain Optical Methods in Biomedical Science and Clinical Applications’, Ed. By V. Tuchin, H. Podbielska, and B. Ovrin, Proc. Soc. Photo-Opt. Ins., SPIE 2981, 78 (1997).Search in Google Scholar

[18] E. Lankenau, D. Klinger, C. Winter, A. Malik, H. Müller, et al., in ‘Combining Optical Coherence Tomography (OCT) With an Operating Microscope’, Ed. By T.M. Buzug et al. (Springer Berlin, Heidelberg, New York, 2007), ISBN 978-3-540-68763-4, pp. 343ff.Search in Google Scholar

[19] E. Lankenau, D. Klinger, H.H. Müller, A. Malik, C. Winter, et al., Med. Laser Appl. 24(2), 127 (2009).10.1016/j.mla.2009.02.014Search in Google Scholar

[20] R. Luthe, Ophthalmol. Manage. 16, 8 (2012).Search in Google Scholar

[21] S. Binder, C.I. Falkner-Radler, C. Hauger, H. Matz, and C. Glittenberg, Retina-J. Ret. Vit. Dis. 31(7), 1332 (2011).10.1097/IAE.0b013e3182019c18Search in Google Scholar PubMed

[22] M. Doors, T.T. Berendschot, J. de Brabander, C.A. Webers, and R.M. Nuijts, J. Cataract Refr. Surg. 36, 1213 (2010).Search in Google Scholar

[23] J.P. Ehlers, Y.K. Tao, S. Farsiu, R. Maldonado, J.A. Izatt, et al., Invest. Ophthalmol. Vis. Sci. 52(6), 3153 (2011).10.1167/iovs.10-6720Search in Google Scholar PubMed PubMed Central

[24] P.B. Knecht, C. Kaufmann, M.N. Menke, S.L. Watson, and M.M. Bosch, Am. J. Ophthalmol. 150(3), 360 (2010).10.1016/j.ajo.2010.04.017Search in Google Scholar PubMed

[25] S. Houston, A.M. Berrocal, and T.G. Murray, Retinal Physician, 1 September (2011).Search in Google Scholar

[26] E. Lankenau, Dissertation, ISBN: 3-89825-674-X (2003).Search in Google Scholar

[27] T. Just, E. Lankenau, F. Prall, G. Hüttmann, H.W. Pau, and K. Sommer, Laryngoscope 120(10), 1964–1970 (2010).10.1002/lary.21057Search in Google Scholar PubMed

[28] H.J. Böhringer, D. Boller, J. Leppert, U. Knopp, E. Lankenau, et al., Lasers Surg. Med. 38, 588–597 (2006).Search in Google Scholar

Received: 2013-2-28
Accepted: 2013-4-17
Published Online: 2013-05-14
Published in Print: 2013-06-01

©2013 by THOSS Media & De Gruyter Berlin Boston

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