Positron emission tomography (PET) is an established medical diagnostic imaging method. Continuous improvements are aimed at refining image reconstruction, reducing the amount of radioactive tracer and combining with targeted therapy. Time-of-flight (TOF)-PET provides the localization of the tracer through improved time resolution, nuclear physics may contribute to this goal via selection of radioactive nuclei emitting additional γ-rays. This additional radiation, when properly detected, localizes the decay of the tracer at the line of response (LoR) determined by two detected 511 keV quanta. Selected candidates are presented. Some are particularly interesting, as they are strong candidates for theranostic applications.
I am grateful to Dr. Mateusz Sitarz and the late professor Jerzy Jastrzȩbski for pointing to me their vision of medical applications of nuclear physics. The help of Joanna Matulewicz in making graphics is acknowledged.
Research funding: None declared.
Author contributions: Author has accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Author states no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The local Institutional Review Board deemed the study exempt from review.
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