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Licensed Unlicensed Requires Authentication Published by De Gruyter June 18, 2011

The multidrug transporter Pdr5: a molecular diode?

Rakeshkumar P. Gupta, Petra Kueppers, Lutz Schmitt and Robert Ernst
From the journal

Abstract

A subset of the family of ATP-binding cassette (ABC) transporters has been in focus owing to their involvement in conferring multidrug resistance in cancer cells and among immune compromised individuals. Saccharomyces cerevisiae is protected against xenobiotics by similar machineries that are part of the pleitropic drug resistance (PDR) network. The ABC transporter Pdr5 is an important member of this PDR network in yeast and is involved in cellular detoxification by the efflux of a wide variety of drugs and substrates. In this review, we focus on the aspects of detergent effects and the degeneracy in conserved sequences that is observed in the nucleotide binding domains of Pdr5 and discuss their functional relevance.


Corresponding authors

Received: 2010-9-3
Accepted: 2010-10-12
Published Online: 2011-06-18
Published in Print: 2011-02-01

©2011 by Walter de Gruyter Berlin New York