Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter June 18, 2011

Evolution of YidC/Oxa1/Alb3 insertases: three independent gene duplications followed by functional specialization in bacteria, mitochondria and chloroplasts

  • Soledad Funes , Frank Kauff , Eli O. van der Sluis , Martin Ott and Johannes M. Herrmann EMAIL logo
From the journal Biological Chemistry


Members of the YidC/Oxa1/Alb3 protein family facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria and the thylakoid membrane of plastids. All homologs share a conserved hydrophobic core region comprising five transmembrane domains. On the basis of phylogenetic analyses, six subgroups of the family can be distinguished which presumably arose from three independent gene duplications followed by functional specialization. During evolution of bacteria, mitochondria and chloroplasts, subgroup-specific regions were added to the core domain to facilitate the association with ribosomes or other components contributing to the substrate spectrum of YidC/Oxa1/Alb3 proteins.

Corresponding author

Received: 2010-7-26
Accepted: 2010-10-20
Published Online: 2011-06-18
Published in Print: 2011-02-01

©2011 by Walter de Gruyter Berlin New York

Downloaded on 29.2.2024 from
Scroll to top button