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BY-NC-ND 4.0 license Open Access Published by De Gruyter Open Access April 21, 2017

Glass-based coatings on biomedical implants: a state-of-the-art review

  • Francesco Baino EMAIL logo and Enrica Verné
From the journal Biomedical Glasses


Bioactive glasses, invented by Prof. Larry L. Hench in the late 1960s, have revolutionized the field of biomaterials as they were shown to tightly bond to both hard and soft living tissues and to stimulate cells towards a path of regeneration and self-repair. However, due to their relatively poor mechanical properties (brittleness, low bending strength and fracture toughness), they are generally unsuitable for load-bearing applications. On the other hand, bioactive glasses have been successfully applied as coatings on the surface of stronger/tougher substrates to combine adequate mechanical properties with high bioactivity and, in some cases, additional extrafunctionalities (e.g. antibacterial properties, drug release). After giving a short overview of the main issues concerning the fabrication of glass coatings, this review provides a state-of-the-art picture in the field and specifically discusses the development of bioactive and hierarchical coatings on 3D porous scaffolds, joint prostheses, metallic substrates (e.g. wires or nails) for orthopedic fixation, polymeric meshes and sutures for wound healing, ocular implants and percutaneous devices.


[1] Rahaman M.N., Day D.E., Bal B.S., Fu Q., Jung S.B., Bonewald L.F., Tomsia A.P., Bioactive Glass in Tissue Engineering, Acta Biomater 2011, 7, 2355-2373.10.1016/j.actbio.2011.03.016Search in Google Scholar PubMed PubMed Central

[2] Hoppe A., Guldal N., Boccaccini A.R., Biological Response to Ionic Dissolution Products from Bioactive Glass and Glass- Ceramics in the Context of Bone Tissue Engineering, Biomaterials 2011, 32, 2757-2774.10.1016/j.biomaterials.2011.01.004Search in Google Scholar PubMed

[3] Mahmood Rabiee S., Nazparvar N., Azizian M., Vashaee D., Tayebi L., Effect of Ion Substitution on Properties of Bioactive Glasses: a Review, Ceram Int 2015, 41, 7241-7251.10.1016/j.ceramint.2015.02.140Search in Google Scholar

[4] Hench L.L., Splinter R.J., Allen W.C., Greenlee T.K., Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials, J Biomed Mater Res 1971, 5, 117-141.10.1002/jbm.820050611Search in Google Scholar

[5] Hench L.L., The Story of Bioglassr, JMater SciMater Med 2006, 17, 967-978.10.1007/s10856-006-0432-zSearch in Google Scholar PubMed

[6] Jones J.R., Review of Bioactive Glass: from Hench to Hybrids, Acta Biomater 2013, 9, 4457-4486.10.1016/j.actbio.2012.08.023Search in Google Scholar PubMed

[7] Kaur G., Pandey O.P., Singh K., Homa D., Scott B., Pickrell G., A Review of Bioactive Glasses: their Structure, Properties, Fabrication, and Apatite Formation, J Biomed Mater Res A 2014, 102, 254-274.10.1002/jbm.a.34690Search in Google Scholar PubMed

[8] Baino F., Novajra G., Miguez-Pacheco V., Boccaccini A.R., Vitale- Brovarone C., Bioactive Glasses: Special Applications outside the Skeletal System, J Non-Cryst Solids 2016, 432, 15-30.10.1016/j.jnoncrysol.2015.02.015Search in Google Scholar

[9] Rezwan K., Chen Q.Z., Blaker J.J., Boccaccini A.R., Biodegradable and Bioactive Porous Polymer/Inorganic Composite Scaffolds for Bone Tissue Engineering, Biomaterials 2006, 27, 3413-3431.10.1016/j.biomaterials.2006.01.039Search in Google Scholar PubMed

[10] Sola A., Bellucci D., Cannillo V., Cattini A., Bioactive Glass Coatings: a Review, Surf Eng 2011, 27, 560-572.10.1179/1743294410Y.0000000008Search in Google Scholar

[11] McEntire B.J., Bal B.S., Rahaman M.N., Chevalier J., Pezzotti G., Ceramics and Ceramic Coatings in Orthopaedics, J Eur Ceram Soc 2015, 35, 4327-4369.10.1016/j.jeurceramsoc.2015.07.034Search in Google Scholar

[12] Verné E., Bioactive glass and glass-ceramic coatings, In: Jones J.R., Clare A.G. (Eds.), Bio-glasses: an introduction, Wiley, Chichester (UK), 2012.Search in Google Scholar

[13] Sun L., Berndt C.C., Gross K.A., Kucuk A., Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: a review, J Biomed Mater Res (Appl Biomater) 2001, 58, 570-592.10.1002/jbm.1056Search in Google Scholar

[14] Gomez-Vega J.M., Saiz E., Tomsia A.P., Oku T., Suganuma K., Marshall G.W., Marshall S.J., Novel Bioactive Functionally Graded Coatings on Ti6Al4V, Adv Mater 2000, 12, 894-898.10.1002/1521-4095(200006)12:12<894::AID-ADMA894>3.0.CO;2-4Search in Google Scholar

[15] Lopez-Esteban S., Saiz E., Fujino S., Oku T., Suganuma K., Tomsia A.P., Bioactive Glass Coatings for Orthopedic Metallic Implants, J Eur Ceram Soc 2003, 23, 2921-2930.10.1016/S0955-2219(03)00303-0Search in Google Scholar

[16] Lopez-Esteban S., Gutierrez-Gonzalez C.F., Gremillard L., Saiz E., Tomsia A.P., Interfaces in Graded Coatings on Titanium- Based Implants, J Biomed Mater Res A 2009, 88, 1010-1021.10.1002/jbm.a.31935Search in Google Scholar

[17] Baino F., Marshall M., Kirk N., Vitale-Brovarone C., Design, Selection and Characterization of Novel Glasses and Glass- Ceramics for use in Prosthetic Applications, Ceram Int 2016, 42, 1482-1491.10.1016/j.ceramint.2015.09.094Search in Google Scholar

[18] Roether J.A., Boccaccini A.R., Hench L.L., Maquet V., Gautier S., Jerome R., Development and In Vitro Characterisation of Novel Bioresorbable and Bioactive Composite Materials Based on Polylactide Foams and Bioglassr for Tissue Engineering Applications, Biomaterials 2002, 23, 3871-3878.10.1016/S0142-9612(02)00131-XSearch in Google Scholar

[19] Boccaccini A.R., Keim S., Ma R., Li Y., Zhitomirsky I., Electrophoretic Deposition of Biomaterials, J R Soc Interface 2010, 7, S581-S613.10.1098/rsif.2010.0156.focusSearch in Google Scholar

[20] Bil M., Ryszkowska J., Roether J.A., Bretcanu O., Boccaccini A.R., Bioactivity of Polyurethane-Based Scaffolds Coated with Bioglassr, Biomed Mater 2007, 2, 93-101.10.1088/1748-6041/2/2/006Search in Google Scholar

[21] Baino F., Verné E., Vitale-Brovarone C., Feasibility, Tailoring and Properties of Polyurethane/Bioactive Glass Composite Scaffolds for Tissue Engineering, J Mater Sci Mater Med 2009, 20, 2189-2195.10.1007/s10856-009-3787-0Search in Google Scholar

[22] Cabanas-Polo S., Philippart A., Boccardi E., Hazur J., Boccaccini A.R., Facile Production of Porous Bioactive Glass Scaffolds by the Foam Replica Technique Combined with Sol- Gel/Electrophoretic Deposition, Ceram Int 2016, 42, 5772-5777.10.1016/j.ceramint.2015.12.115Search in Google Scholar

[23] Mohamad Yunos D., Bretcanu O., Boccaccini A.R. Polymer- Bioceramic Composites for Tissue Engineering Scaffolds, J Mater Sci 2008, 43, 4433-4442.10.1007/s10853-008-2552-ySearch in Google Scholar

[24] Baino F., Vitale-Brovarone C., Three-Dimensional Glass-Derived Scaffolds for Bone Tissue Engineering: Current Trends and Forecasts for the Future, J Biomed Mater Res A 2011, 97, 514-535.10.1002/jbm.a.33072Search in Google Scholar PubMed

[25] Miao X., Modification of Porous Alumina Ceramics with Bioinert and Bioactive Glass Coatings, AdvMater Res 2008, 32, 211-214.10.4028/ in Google Scholar

[26] Liu J., Dong Z., Miao X., Porous Alumina/Zirconia Composite Scaffold with Bioactive Glass 58S33C Coating, J Biomimetics Biomater Tissue Eng, 2010, 6, 87-104.10.4028/ in Google Scholar

[27] Ria L., Rodal P., Lopez-Alvarez M., Borrajo J.P., Solla E., Serra J., Gonzalez P., Leon B, Bioceramic Coatings on Biomorphic SiC by Electrophoretic Deposition,Mater Sci Forum2008, 587-588, 86-90.10.4028/ in Google Scholar

[28] Jun I.K., Song J.H., Choi W.Y., Koh Y.H., Kim H.E., Porous Hydroxyapatite Scaffolds Coated with Bioactive Apatite-Wollastonite Glass-Ceramics, J Am Ceram Soc 2007, 90, 2703-2708.10.1111/j.1551-2916.2007.01762.xSearch in Google Scholar

[29] Esfahani S.I.R., Tavangarian F., Emadi R., Nanostructured Bioactive Glass Coating on Porous Hydroxyapatite Scaffold for Strength Enhancement, Mater Lett 2008, 62, 3428-3430.10.1016/j.matlet.2008.02.061Search in Google Scholar

[30] Esfahani S.I.R., Nouri-Khorasani S., Lu Z.F., Appleyard R.C., Zreiqat H, Effects of Bioactive Glass Nanoparticles on the Mechanical and Biological Behavior of Composite Coated Scaffolds. Acta Biomater 2011, 7, 1307-1318.10.1016/j.actbio.2010.10.015Search in Google Scholar PubMed

[31] Yazdimamaghani M., Razavi M., Vashaee D., Raveendra Pothineni V., Rajadas J., Tayebi L., Significant Degradability Enhancement in Multilayer Coating of Polycaprolactone-Bioactive Glass/Gelatin-Bioactive Glass on Magnesium Scaffold for Tissue Engineering Applications, Appl Surf Sci 2015, 338, 137-145.10.1016/j.apsusc.2015.02.120Search in Google Scholar

[32] Li N., Zheng Y., NovelMagnesiumAlloys Developed for Biomedical Application: a Review, JMater Sci Technol 2013, 29, 489-502.10.1016/j.jmst.2013.02.005Search in Google Scholar

[33] Mourino V., Boccaccini A.R., Bone Tissue Engineering Therapeutics: Controlled Drug Delivery in Three Dimensional Scaffolds, J R Soc Interface 2010, 7, 209-227.10.1098/rsif.2009.0379Search in Google Scholar PubMed PubMed Central

[34] Arcos D., Vallet-Regí M., Bioceramics for Drug Delivery, Acta Mater 2013, 61, 890-911.10.1016/j.actamat.2012.10.039Search in Google Scholar

[35] Cauda V., Fiorilli S., Onida B., Verné E., Vitale-Brovarone C., Viterbo D., Croce G., Milanesio M., Garrone E., SBA-15 Ordered Mesoporous Silica inside a Bioactive Glass-Ceramic Scaffold for Local Drug Delivery, JMater SciMater Med 2008, 19, 3303-3310.10.1007/s10856-008-3468-4Search in Google Scholar PubMed

[36] Mortera R., Onida B., Fiorilli S., Cauda V., Vitale-Brovarone C., Baino F., Verné E., Garrone E., Synthesis of MCM-41 Spheres inside Bioactive Glass-Ceramic Scaffold, Chem Eng J 2008, 137, 54-61.10.1016/j.cej.2007.07.094Search in Google Scholar

[37] Vitale-Brovarone C., Baino F., Miola M., Mortera R., Onida B., Verné E., Glass-Ceramic Scaffolds Containing Silica Mesophases for Bone Grafting and Drug Delivery, J Mater Sci Mater Med 2009, 20, 809-820.10.1007/s10856-008-3635-7Search in Google Scholar PubMed

[38] Mortera R., Baino F., Croce G., Fiorilli S., Vitale-Brovarone C., Verné E., Onida B., Monodisperse Mesoporous Silica Spheres inside a Bioactive Macroporous Glass-Ceramic Scaffold, Adv Eng Mater 2010, 12, B256-B259.10.1002/adem.200980075Search in Google Scholar

[39] Boccardi E., Philippart A., Juhasz-Bortuzzo J., Beltran A., Novajra G., Vitale-Brovarone C., Spiecker E., Boccaccini A.R., Uniform Surface Modification of 3D Bioglassr-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability, Front Bioeng Biotechnol 2015, 3, 177.10.3389/fbioe.2015.00177Search in Google Scholar PubMed PubMed Central

[40] Horcajada P., Ramila A., Boulahya K., Gonzalez-Calbet J., Vallet- Regi M., Bioactivity in Ordered Mesoporous Materials, Solid State Sci 2004, 6, 1295-1300.10.1016/j.solidstatesciences.2004.07.026Search in Google Scholar

[41] Izquierdo-Barba I., Ruiz-Gonzalez L., Doadrio J.C., Gonzalez- Calbet J.M., Vallet-Regi M, Tissue Regeneration: a New Property of Mesoporous Materials, Solid State Sci 2005, 7, 983-989.10.1016/j.solidstatesciences.2005.04.003Search in Google Scholar

[42] Izquierdo-Barba I., Vallet-Regi M., Mesoporous Bioactive Glasses: Relevance of Their Porous Structure Compared to That of Classical Bioglasses, Biomed Glasses 2015, 1, 140-150.10.1515/bglass-2015-0014Search in Google Scholar

[43] Fiorilli S., Baino F., Cauda V., Crepaldi M., Vitale-Brovarone C., Demarchi D., Onida B., Electrophoretic Deposition of Mesoporous Bioactive Glass on Glass-ceramic Foam Scaffolds for Bone Tissue Engineering, J Mater Sci Mater Med 2015, 26, 21.10.1007/s10856-014-5346-6Search in Google Scholar

[44] Zhang Y., Xia L., Zhai D., Shi M., Luo Y., Feng C., Fang B., Yin J., Chang J., Wu C., Mesoporous Bioactive Glass Nanolayer- Functionalized 3D-Printed Scaffolds for Accelerating Osteogenesis and Angiogenesis, Nanoscale 2015, 7, 19207-19221.10.1039/C5NR05421DSearch in Google Scholar

[45] Wu C., Zhang Y., Zhu Y., Friis T., Xiao Y., Structure-Property Relationships of Silk-Modified Mesoporous Bioglass Scaffolds, Biomaterials 2010, 31, 3429-3438.10.1016/j.biomaterials.2010.01.061Search in Google Scholar

[46] Shi M., Zhai D., Zhao L.,Wu C., Chang J., Nanosized Mesoporous Bioactive Glass/Poly(lactic-co-glycolic Acid) Composite-Coated CaSiO3 Scaffolds with Multifunctional Properties for Bone Tissue Engineering, BioMed Res Int 2014, Article ID 32304610.1155/2014/323046Search in Google Scholar

[47] Rahaman M.N., Yao A., Sonny Bal B., Garino J.P., Ries N.D., Ceramics for Prosthetic Hip and Knee Joint Replacement, J Am Ceram Soc, 2007, 90, 1965-1988.10.1111/j.1551-2916.2007.01725.xSearch in Google Scholar

[48] Jaffe W.L., Scott D.F., Current Concepts Review - Total Hip Arthroplasty with Hydroxyapatite-Coated Prostheses, J Bone Joint Surg 1996, 78, 1918-1934.10.2106/00004623-199612000-00018Search in Google Scholar

[49] Griss P., Greenspan D.C., Heimke G., Krempien B., Buchinger R., Hench L.L., Jentschura J., Evaluation of a Bioglass-Coated Al2O3 Total Hip Prosthesis in Sheep, J BiomedMater Res 1976, 10, 511-518.10.1002/jbm.820100406Search in Google Scholar

[50] Hamadouche M., Meunier A., Greenspan D.C., Blanchat C.,Zhong J.P., LaTorre G.P., Sedel L., Bioactivity of Sol-Gel Bioactive Glass Coated Alumina Implants, J Biomed Mater Res 2000, 52, 422-429.10.1002/1097-4636(200011)52:2<422::AID-JBM24>3.0.CO;2-PSearch in Google Scholar

[51] Verné E., Vitale-Brovarone C., Robiglio L., Baino F., Single-Piece Ceramic Prosthesis Elements, EU Patent no. EP2152328 (WO 2008/146322 A2), 2008.Search in Google Scholar

[52] Vitale-Brovarone C., Baino F., Tallia F., Gervasio C., Verné E., Bioactive Glass-Derived Trabecular Coating: a Smart Solution for Enhancing Osteointegration of Prosthetic Elements, J Mater Sci Mater Med 2012, 23, 2369-2380.10.1007/s10856-012-4643-1Search in Google Scholar

[53] Baino F., Vitale-Brovarone C., Feasibility of Glass-Ceramic Coatings on Alumina Prosthetic Implants by Airbrush Spraying Method, Ceram Int 2015, 41, 2150-2159.10.1016/j.ceramint.2014.10.015Search in Google Scholar

[54] Baino F., Vitale-Brovarone C., Wollastonite-Containing Bioceramic Coatings on Alumina Substrates: Design Considerations and Mechanical Modelling, Ceram Int 2015, 41, 11464-11470.10.1016/j.ceramint.2015.05.111Search in Google Scholar

[55] Baino F., Tallia F., Novajra G., Minguella J., Montealegre M.A., Korkusuz F., Vitale-Brovarone C., Novel Bone-Like Porous Glass Coatings on Al2O3 Prosthetic Substrates, Key Eng Mater 2015, 631, 236-240.10.4028/ in Google Scholar

[56] Baino F., Vitale-Brovarone C., Trabecular Coating on Curved Alumina Substrates Using a Novel Bioactive and Strong Glass- Ceramic, Biomed Glasses 2015, 1, 31-40.10.1515/bglass-2015-0003Search in Google Scholar

[57] Baino F., Minguella J., Kirk N., Montealegre M.A., Fiaschi C., Korkusuz F., Orlygsson G., Vitale-Brovarone C., Novel Full-Ceramic Monoblock Acetabular Cup with a Bioactive Trabecular Coating: Design, Fabrication and Characterization, Ceram Int 2016, 42, 6833-6845.10.1016/j.ceramint.2016.01.065Search in Google Scholar

[58] ASTM C633, Standard Test Method for Adhesion or Cohesion Strength of Thermal Spray Coatings, 2008.Search in Google Scholar

[59] Alonso-Barrio J.A., Sanchez-Herraez S., Fernandez-Hernandez O., Betegon-Nicolas J., Gonzalez-Fernandez J.J., Lopez-Sastre A., Bioglass-Coated Femoral Stem, J Bone Joint Surg 2004, 86B (Suppl II), 138.Search in Google Scholar

[60] Drnovšek N., Novak S., Dragin U., Čeh M., Gorenšek M., Gradišar M., Bioactive Glass Enhances Bone Ingrowth into the Porous Titanium Coating on Orthopaedic Implants, Int Orthop (SICOT) 2012, 36, 1739-1745. 10.1007/s00264-012-1520-ySearch in Google Scholar

[61] Schrooten J., Helsen J.A., Adhesion of Bioactive Glass Coating to Ti6Al4V Oral Implant, Biomaterials, 2000, 21, 1461-1469.10.1016/S0142-9612(00)00027-2Search in Google Scholar

[62] Lopez Calvo V., Vicent Cabedo M., Bannier E., Canas Recacha E., Boccaccini A.R., Cordero Arias L., Sanchez Vilches E., 45S5 Bioactive Glass Coatings by Atmospheric Plasma Spraying Obtained from Feedstocks Prepared by Different Routes, J Mater Sci 2014, 49, 7933-7942.10.1007/s10853-014-8519-2Search in Google Scholar

[63] Pishbin F., Simchi A., Ryan M.P., Boccaccini A.R., Electrophoretic Deposition of Chitosan/45S5 Bioglassr Composite Coatings for Orthopaedic Applications, Surf Coatings Technol 2011, 205, 5260-5268.10.1016/j.surfcoat.2011.05.026Search in Google Scholar

[64] Miola M., Verné E., Ciraldo F.E., Cordero-Arias L., Boccaccini A.R., Electrophoretic Deposition of Chitosan/45S5 Bioactive Glass Composite Coatings Doped with Zn and Sr, Front Bioeng Biotechnol 2015, 3, 159.10.3389/fbioe.2015.00159Search in Google Scholar PubMed PubMed Central

[65] Chen Q., Cordero-Arias L., Roether J.A., Cabanas-Polo S., Virtanen S., Boccaccini A.R., Alginate/Bioglassr Composite Coatings on Stainless Steel Deposited by Direct Current and Alternating Current Electrophoretic Deposition, Surf Coatings Technol 2013, 233, 49-56.10.1016/j.surfcoat.2013.01.042Search in Google Scholar

[66] Moskalewicz T., Seuss S., Boccaccini A.R., Microstructure and Properties of Composite Polyetheretherketone/Bioglassr Coatings deposited on Ti-6Al-7Nb Alloy for Medical Applications, Appl Surf Sci 2013, 273, 62-67.10.1016/j.apsusc.2013.01.174Search in Google Scholar

[67] Seuss S., Lehmann M., Boccaccini A.R., Alternating Current Electrophoretic Deposition of Antibacterial Bioactive Glass- Chitosan Composite Coatings, Int J Mol Sci 2014, 15, 12231-12242.10.3390/ijms150712231Search in Google Scholar

[68] Pishbin F. Mourino V., Gilchrista J.B., Kreppel S., McComb D.W., Salih V., Ryan M.P., Boccaccini A.R., Single-Step Electrochemical Deposition of Antimicrobial Orthopaedic Coatings Based on Bioactive Glass/Chitosan/Nano-Silver Composite System, Acta Biomater 2013, 9, 7469-7479.10.1016/j.actbio.2013.03.006Search in Google Scholar

[69] Seuss S., Heinloth M., Boccaccini A.R., Development of Bioactive Composite Coatings Based on Combination of PEEK, Bioactive Glass and Ag Nanoparticles with Antimicrobial Properties, Surf Coatings Technol 2016, 301, 100-105.10.1016/j.surfcoat.2016.03.057Search in Google Scholar

[70] Stamboulis A.G., Boccaccini A.R., Hench L.L., Novel Biodegradable Polymer/Bioactive Glass Composites for Tissue Engineering Applications, Adv Eng Mater 2002, 4, 105-109.10.1002/1527-2648(200203)4:3<105::AID-ADEM105>3.0.CO;2-LSearch in Google Scholar

[71] Stamboulis A., Hench L.L., Boccaccini A.R., Mechanical Properties of Biodegradable Polymer Sutures Coated with Bioactive Glass, J Mater Sci Mater Med 2002, 13, 843-848.10.1023/A:1016544211478Search in Google Scholar

[72] Bretcanu O., Verné E., Borello L, Boccaccini A.R., Bioactivity of Degradable Polymer Sutures Coated with Bioactive Glass, J Mater Sci Mater Med 2004, 15, 893-899.10.1023/B:JMSM.0000036277.99450.a2Search in Google Scholar

[73] Boccaccini A.R., Stamboulis A.G., Rashid A., Roether J.A., Composite Surgical Sutures with Bioactive Glass Coating, J Biomed Mater Res B 2003, 67, 618-626.10.1002/jbm.b.10047Search in Google Scholar

[74] Boccaccini A.R., Minay E.J., Krause D., Bioglass Coatings on Superelastic NiTi Wires by Electrophoretic Deposition (EPD), Key Eng Mater 2006, 314, 219-224.10.4028/ in Google Scholar

[75] Boccaccini A.R., Peters C., Roether J.A., Eifler D., Misra S.K., Minay E.J., Electrophoretic Deposition of Polyetheretherketone (PEEK) and PEEK/Bioglass Coatings on NiTi Shape Memory Alloy Wires, J Mater Sci 2006, 41, 8152-8159.10.1007/s10853-006-0556-zSearch in Google Scholar

[76] Esfahani S.I.R., Ebrahimi-Kahrizsangi R., Saleh D.M., Karbasi S., Bonding Strength, Hardness and Bioactivity of Nano Bioglass- Titania Nano Composite Coating Deposited on NiTi Nails, Curr Nanosci 2011, 7, 568-575.10.2174/157341311796196844Search in Google Scholar

[77] Wilson J., Pigott G.H., Schoen F.J., Hench L.L., Toxicology and Biocompatibility of Bioglasses, J Biomed Mater Res 1981, 15, 805-817.10.1002/jbm.820150605Search in Google Scholar PubMed

[78] Miguez-Pacheco V., Hench L.L., Boccaccini A.R., Bioactive Glasses Beyond Bone and Teeth: Emerging Applications in Contact with Soft Tissues, Acta Biomater 2015, 13, 1-15.10.1016/j.actbio.2014.11.004Search in Google Scholar PubMed

[79] Miguez-Pacheco V., Greenspan D., Hench L.L., Boccaccini A.R. Bioactive Glasses in Soft Tissue Repair, Am Ceram Soc Bull 2015, 94, 27-31.Search in Google Scholar

[80] Gurtner G.C., Werner S., Barrandon Y., Longaker M.T., Wound Repair and Regeneration, Nature 2008, 453, 314-321.10.1038/nature07039Search in Google Scholar PubMed

[81] Blaker J.J., Nazhat S.N., Boccaccini A.R., Development and Characterisation of Silver-Doped Bioactive Glass-Coated Sutures for Tissue Engineering and Wound Healing Applications, Biomaterials 2004, 25, 1319-1329.10.1016/j.biomaterials.2003.08.007Search in Google Scholar PubMed

[82] Pratten J., Nazhat S.N., Blaker J.J., Boccaccini A.R., In Vitro Attachment of Staphylococcus Epidermidis to Surgical Sutures with and without Ag-Containing Bioactive Glass Coating, J Biomater Appl 2004, 19, 47-57.10.1177/0885328204043200Search in Google Scholar PubMed

[83] Chernousova S., Epple M., Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal, Angew Chem Int Ed 2013, 52, 1636-1653.10.1002/anie.201205923Search in Google Scholar PubMed

[84] Salah Hameed A., Al-Warid R.J., Abass Obaid I., Anti-bacterial Action of Multi-component Bioactive Glass Coating for Surgical Suture, J Babylon Univ Pure Appl Sci 2016, 24, 1395-1400.Search in Google Scholar

[85] Shah Mohammadi M., Stähli C., Nazhat S.N., Bioactive glasses for wound healing, In: Ylänen H.O. (Ed.), Bioactive glasses: materials, properties and applications, Woodhead Publishing Ltd (Elsevier), Amsterdam, 2011, pp. 246-266.Search in Google Scholar

[86] Baino F., How Can Bioactive Glasses Be Useful in Ocular Surgery?, J Biomed Mater Res A 2015, 103, 1259-1275.10.1002/jbm.a.35260Search in Google Scholar PubMed

[87] Baino F., Perero S., Ferraris S., Miola M., Balagna C., Verné E., Vitale-Brovarone C., Coggiola A., Dolcino D., Ferraris M., Biomaterials for Orbital Implants and Ocular Prostheses: Overview and Future Prospects, Acta Biomater 2014, 10, 1064-1087.10.1016/j.actbio.2013.12.014Search in Google Scholar PubMed

[88] Naik M.N., Murthy R.K., Honavar S.G., Comparison of Vascularization of Medpor and Medpor-Plus Orbital Implants: a Prospective, Randomized Study, Ophthal Plast Reconstr Surg 2007, 23, 463-467.10.1097/IOP.0b013e318158ec8eSearch in Google Scholar

[89] Ma X., Schou K.R., Maloney-Schou M., Harwin F.M., Ng J.D., The Porous Polyethylene/Bioglass Spherical Orbital Implant: a Retrospective Study of 170 Cases, Ophthal Plast Reconstr Surg 2011, 27, 21-27.10.1097/IOP.0b013e3181de01a7Search in Google Scholar

[90] Ye J., He J., Wang C., Yao K, Gou Z., Copper-Containing Mesoporous Bioactive Glass Coatings on Orbital Implants for Improving Drug Delivery Capacity and Antibacterial Activity, Biotechnol Lett 2014, 36, 961-968.10.1007/s10529-014-1465-xSearch in Google Scholar

[91] Baino F., Ferraris S., Miola M., Perero S., Verné E., Coggiola A., Dolcino D., Ferraris M., Novel Antibacterial Ocular Prostheses: Proof of Concept and Physico-Chemical Characterization,Mater Sci Eng C 2016, 60, 467-474.10.1016/j.msec.2015.11.075Search in Google Scholar

[92] Baino F., Ferraris S., Miola M., Ferraris M., Antibacterial Nanocoatings for Ocular Applications, Adv Sci Technol 2017, 102, 24-28.10.4028/ in Google Scholar

[93] Gomaa A., Comyn O., Liu C., Keratoprostheses in Clinical Practice - a Review, Clin Exp Ophthlmol 2010, 38, 211-224.10.1111/j.1442-9071.2010.02231.xSearch in Google Scholar

[94] Linnola R.J., Happonen R.P., Andersson O.H., Vedel E.A., Yli- Urpo U., Krause U., Laatikainen L., Titaniumand Bioactive Glass- Ceramic Coated TitaniumasMaterials for Keratoprosthesis, Exp Eye Res 1996, 63, 471-478. 10.1006/exer.1996.0137Search in Google Scholar

[95] Meyer J.U., Retina Implant - a BioMEMS Challenge, Sens Actuat A 2002, 97-98, 1-9.10.1016/S0924-4247(01)00807-XSearch in Google Scholar

[96] Ong J.M., Da Cruz L., The Bionic Eye: a Review, Clin Exp Ophthalmol 2012, 40, 6-17.10.1111/j.1442-9071.2011.02590.xSearch in Google Scholar PubMed

[97] Bilsel Y., Abci I., The Search for Ideal Hernia Repair: Mesh, Materials and Types, Int J Surg 2012, 10, 317-321.10.1016/j.ijsu.2012.05.002Search in Google Scholar PubMed

[98] Muzio G., Perero S., Miola M., Oraldi M., Ferraris S., Verné E., Festa F., Canuto R.A., Festa V., Ferraris M., Biocompatibility versus Peritoneal Mesothelial Cells of Polypropylene Prostheses for Hernia Repair, Coated with a Thin Silica/Silver Layer, J Biomed Mater Res B, in press. DOI: 10.1002/jbm.b.3369710.1002/jbm.b.33697Search in Google Scholar PubMed

[99] Twardowski Z.J., Nichols W.K., Peritoneal dialysis access and exit site care including surgical aspects, In: Gokal R., Khanna R., Krediet R., Nolph K. (Eds.), Textbook of Peritoneal Dialysis, Amsterdam, Kluwer Academic Publishers, 2000, pp. 307-362.10.1007/978-94-017-3225-3_9Search in Google Scholar

[100] Marotta J.S., LaTorre G., Batich C., Hench L.L., Percutaneous Biofixed Medical Implants, US Patent no. US5990380 A, 1999.Search in Google Scholar

[101] Ross E.A., Batich C.D., Clapp W.L., Sallustio J.E., Lee N.C., Tissue Adhesion to Bioactive Glass-Coated Silicone Tubing in a Rat Model of Peritoneal Dialysis Catheters and Catheter Tunnels, Kidney Int 2003, 63, 702-708.10.1046/j.1523-1755.2003.00764.xSearch in Google Scholar PubMed

Received: 2016-11-14
Revised: 2017-3-22
Accepted: 2017-4-2
Published Online: 2017-4-21
Published in Print: 2017-4-25

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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