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Publicly Available Published by De Gruyter May 16, 2012

Small GTPase Ran and Ran-binding proteins

Masahiro Nagai and Yoshihiro Yoneda
From the journal BioMolecular Concepts


Like many other small GTPases, Ran functions in eukaryotic cells as a molecular switch that cycles between GTP- and GDP-bound forms. Through the proper modulation of the GTP/GDP cycle, Ran functions with a number of Ran-binding proteins to control a broad array of fundamental cellular functions, including nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope and nuclear pore complex formation. Recent studies have revealed that ‘Ran and Ran binding proteins’ are involved in a variety of functions involving cell fate determination, including cell death, cell proliferation, cell differentiation, and malignant transformation. In this review, we discuss recent progress on the functional link between the Ran system and tumorigenesis, which give clues to the molecular understanding of cancer biology.

Corresponding author

Received: 2011-12-29
Accepted: 2012-4-10
Published Online: 2012-05-16
Published in Print: 2012-08-01

©2012 by Walter de Gruyter Berlin Boston

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