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Publicly Available Published by De Gruyter February 22, 2012

Comparing measured and simulated wave directions in the left atrium – a workflow for model personalization and validation

  • Michael Burdumy EMAIL logo , Armin Luik , Peter Neher , Raghed Hanna , Martin W. Krueger , Christopher Schilling , Hans Barschdorf , Cristian Lorenz , Gunnar Seemann , Claus Schmitt , Olaf Doessel and Frank M. Weber
From the journal


Atrial arrhythmias are frequently treated using catheter ablation during electrophysiological (EP) studies. However, success rates are only moderate and could be improved with the help of personalized simulation models of the atria. In this work, we present a workflow to generate and validate personalized EP simulation models based on routine clinical computed tomography (CT) scans and intracardiac electrograms. From four patient data sets, we created anatomical models from angiographic CT data with an automatic segmentation algorithm. From clinical intracardiac catheter recordings, individual conduction velocities were calculated. In these subject-specific EP models, we simulated different pacing maneuvers and measurements with circular mapping catheters that were applied in the respective patients. This way, normal sinus rhythm and pacing from a coronary sinus catheter were simulated. Wave directions and conduction velocities were quantitatively analyzed in both clinical measurements and simulated data and were compared. On average, the overall difference of wave directions was 15° (8%), and the difference of conduction velocities was 16 cm/s (17%). The method is based on routine clinical measurements and is thus easy to integrate into clinical practice. In the long run, such personalized simulations could therefore assist treatment planning and increase success rates for atrial arrhythmias.

Corresponding author: Michael Burdumy, Institute of Biomedical Engineering, KIT, Kaiserstrasse 12, 76131 Karlsruhe, Germany Phone: +49-721-60842650 Fax: +49-721-60842789

Received: 2011-5-26
Accepted: 2012-1-5
Published Online: 2012-2-22
Published in Print: 2012-04-01

©2012 by Walter de Gruyter Berlin Boston

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