Accessible Unlicensed Requires Authentication Published by De Gruyter June 1, 2013

SEP-induced activity and its thermographic cortical representation in a murine model

Klaus-Peter Hoffmann, Roman Ruff and Matthias Kirsch

Abstract

This article is a methodical report on the generation of reproducible changes in brain activity in a murine model. Somatosensory evoked potentials (SEP) are used to generate synchronized cortical activity. After electrical stimulation of mice forelimbs, the potentials were recorded with a flexible thin-film polyimide electrode structure directly from the cortex. Every registration included a simultaneous recording from both hemispheres that repeated four times to reproduce and compare the results. The SEPs in the murine model were shown to generate a very stable signal. The latency of the second positive wave (P2 wave) ranged between 16 and 19 ms, and the N1-P2 amplitude ranged between 39 and 48 µV. In addition, the temperature distribution of the cortex was acquired using infrared thermography. Surface cortical temperature changed during electrical stimulation without a clear hemispheric correlation. These initial results could be a step toward a better understanding of the different synchronized cortical activities and basic methods of evaluation of various mathematical algorithms to detect them.


Corresponding author: Klaus-Peter Hoffmann, Department Medical Engineering and Neuroprosthetics, Fraunhofer Institut für Biomedizinische Technik (IBMT), Ensheimer Strasse 48, 66386 St. Ingbert, Germany, Phone: +49 6894 980 401, Fax: +49 6894 980 408

The work was supported by BMBF 16SV5367, Project elaN.

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Received: 2012-10-31
Accepted: 2013-5-15
Published Online: 2013-06-01
Published in Print: 2013-06-01

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