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Licensed Unlicensed Requires Authentication Published by De Gruyter May 23, 2013

Evaluation of intraoperative optical imaging analysis methods by phantom and patient measurements

  • Martin Oelschlägel EMAIL logo , Tobias Meyer , Hannes Wahl , Stephan B. Sobottka , Matthias Kirsch , Gabriele Schackert and Ute Morgenstern


Intraoperative optical imaging (IOI) is a localization method for functional areas of the human brain cortex during neurosurgical procedures. The aim of the current work was to develop of a new analysis technique for the computation of two-dimensional IOI activity maps that is suited especially for use in clinical routine. The new analysis technique includes a stimulation scheme that comprises 30-s rest and 30-s stimulation conditions, in connection with pixelwise spectral power analysis for activity map calculation. A software phantom was used for verification of the implemented algorithms as well as for the comparison with the commonly used relative difference imaging method. Furthermore, the analysis technique was tested using intraoperative measurements on eight patients. The comparison with the relative difference algorithm revealed an averaged improvement of the signal-to-noise ratio between 95% and 130% for activity maps computed from intraoperatively acquired patient datasets. The results show that the new imaging technique improves the activity map quality of IOI especially under difficult intraoperative imaging conditions and is therefore especially suited for use in clinical routine.

Corresponding author: Martin Oelschlägel, Technische Universität Dresden, Institut für Biomedizinische Technik, D-01062 Dresden, Germany, Phone: +49 351 463 32118, Fax: +49 351 46336026

This work was supported by Carl Zeiss Meditec AG, Oberkochen, Germany, and the Bundesministerium für Bildung und Forschung, Germany. Also, we would like to thank Anita Menschner, Enrico Noback, Titus Troisch, Falk Uhlemann, Hans Dietrich, and Andreas Schöppe for their technical assistance and support.


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Received: 2012-11-9
Accepted: 2013-4-29
Published Online: 2013-05-23
Published in Print: 2013-06-01

©2013 by Walter de Gruyter Berlin Boston

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