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Licensed Unlicensed Requires Authentication Published by De Gruyter September 21, 2019

Effective brain connectivity estimation between active brain regions in autism using the dual Kalman-based method

Mehdi Rajabioun , Ali Motie Nasrabadi EMAIL logo , Mohammad Bagher Shamsollahi and Robert Coben


Brain connectivity estimation is a useful method to study brain functions and diagnose neuroscience disorders. Effective connectivity is a subdivision of brain connectivity which discusses the causal relationship between different parts of the brain. In this study, a dual Kalman-based method is used for effective connectivity estimation. Because of connectivity changes in autism, the method is applied to autistic signals for effective connectivity estimation. For method validation, the dual Kalman based method is compared with other connectivity estimation methods by estimation error and the dual Kalman-based method gives acceptable results with less estimation errors. Then, connectivities between active brain regions of autistic and normal children in the resting state are estimated and compared. In this simulation, the brain is divided into eight regions and the connectivity between regions and within them is calculated. It can be concluded from the results that in the resting state condition the effective connectivity of active regions is decreased between regions and is increased within each region in autistic children. In another result, by averaging the connectivity between the extracted active sources of each region, the connectivity between the left and right of the central part is more than that in other regions and the connectivity in the occipital part is less than that in others.

  1. Author Statement

  2. Research funding: This study was not funded and the authors declare that they have no conflict of interest.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individual participants included in the study.

  5. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Received: 2019-03-11
Accepted: 2019-05-07
Published Online: 2019-09-21
Published in Print: 2020-01-28

©2020 Walter de Gruyter GmbH, Berlin/Boston

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